지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.86 No.6
- 발행연도
- 2014.6
- 수록면
- 309 - 313 (5page)
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초록· 키워드
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Purpose: This study was conducted to evaluate the systemic inflammatory response in colorectal cancer patients, and to estimate the usefulness of the Glasgow prognostic score (GPS) as a prognostic factor.
Methods: Patients with biopsy-proven colorectal adenocarcinoma who were operated between April 2005 and December 2008 were enrolled in this study. The GPS was estimated based on the measurement of CRP and serum albumin level. The GPS was compared with other clinicopathological factors. Univariate and multivariate analyses were performed to evaluate the factors affecting cancer-specific survival.
Results: GPS was significantly higher in patients with anemia, thrombocytosis, a high neutrophil to lymphocyte ratio, tumor of the colon, and large tumor. Patient age, gender, serum CEA level, tumor gross appearance, TNM stage, and tumor differentiation were not related with the GPS. In univariate analysis, hemoglobin, CEA, gross appearance of tumor, TNM stage, tumor differentiation, and GPS were associated with cancer-specific survival. In multivariate analysis, TNM stage (III or IV : I or II; hazard ratio [HR], 12.322; P = 0.015), tumor differentiation (poorly differentiated : well or moderately differentiated; HR, 3.112; P = 0.021), and GPS (GPS 2 : GPS 0 or 1; HR, 5.168; P = 0.003) were identified as independent prognostic factors in colorectal cancer.
Conclusion: Our study showed that the GPS was an independent variable from tumor stage and a good and convenient prognostic factor in colorectal cancer patients.
Methods: Patients with biopsy-proven colorectal adenocarcinoma who were operated between April 2005 and December 2008 were enrolled in this study. The GPS was estimated based on the measurement of CRP and serum albumin level. The GPS was compared with other clinicopathological factors. Univariate and multivariate analyses were performed to evaluate the factors affecting cancer-specific survival.
Results: GPS was significantly higher in patients with anemia, thrombocytosis, a high neutrophil to lymphocyte ratio, tumor of the colon, and large tumor. Patient age, gender, serum CEA level, tumor gross appearance, TNM stage, and tumor differentiation were not related with the GPS. In univariate analysis, hemoglobin, CEA, gross appearance of tumor, TNM stage, tumor differentiation, and GPS were associated with cancer-specific survival. In multivariate analysis, TNM stage (III or IV : I or II; hazard ratio [HR], 12.322; P = 0.015), tumor differentiation (poorly differentiated : well or moderately differentiated; HR, 3.112; P = 0.021), and GPS (GPS 2 : GPS 0 or 1; HR, 5.168; P = 0.003) were identified as independent prognostic factors in colorectal cancer.
Conclusion: Our study showed that the GPS was an independent variable from tumor stage and a good and convenient prognostic factor in colorectal cancer patients.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Trinchieri G. / 2012 / Cancer and inflammation : an old intuition with rapidly evolving new concepts / Annu Rev Immunol 30 : 677 ~ 706
2. [학술지(정기간행물)] - Mantovani A. / 2008 / Cancer-related inflammation / Nature 454 : 436 ~ 444
3. [학술지(정기간행물)] - Triantafillidis JK. / 2009 / Colorectal cancer and inflammatory bowel disease : epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies / Anticancer Res 29 : 2727 ~ 2737
4. [학술지(정기간행물)] - Rostom A. / 2007 / Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer : a systematic review prepared for the U. S. Preventive Services Task Force / Ann Intern Med 146 : 376 ~ 389
5. [학술지(정기간행물)] - Gunter MJ. / 2006 / A prospective study of serum C-reactive protein and colorectal cancer risk in men / Cancer Res 66 : 2483 ~ 2487
2. [학술지(정기간행물)] - Mantovani A. / 2008 / Cancer-related inflammation / Nature 454 : 436 ~ 444
3. [학술지(정기간행물)] - Triantafillidis JK. / 2009 / Colorectal cancer and inflammatory bowel disease : epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies / Anticancer Res 29 : 2727 ~ 2737
4. [학술지(정기간행물)] - Rostom A. / 2007 / Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer : a systematic review prepared for the U. S. Preventive Services Task Force / Ann Intern Med 146 : 376 ~ 389
5. [학술지(정기간행물)] - Gunter MJ. / 2006 / A prospective study of serum C-reactive protein and colorectal cancer risk in men / Cancer Res 66 : 2483 ~ 2487
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