지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 149 - 156 (8page)
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Purpose: Follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC) are two main subtypes of well-differentiated thyroid cancer. Sometimes FTCs present more aggressive features such as vascular invasion. The object of this study was to investigate the clinicopathologic features, prognostic factors and treatment outcome of FTC.
Methods: This retrospective study enrolled 91 patients diagnosed with FTC between November 1994 and October 2008. The clinicopathologic characteristics, treatment outcome and follow up data were analyzed.
Results: The median follow-up (f/u) period was 76.1 months. Distant metastases at the time of diagnosis were detected in 12 patients. During the f/u period, one local recurrence and 4 distant metastases developed. Local recurrence or distant metastasis were noticed in 12 out of 19 patients with widely invasive type and 5 out of 36 patients with minimally invasive type with vascular invasion were also noted. The median times to local recurrence or distant metastasis were 59.0 and 34.2 months, respectively. On analysis, according to the clinocopathologic factors, presence of vascular invasion, extrathyroidal extension, invasion to structure, incomplete excision and pathological classification were independent prognostic factors for recurrence or distant metastasis. Disease specific mortality was seen in one patient.
Conclusion: This study shows that aggressive treatments such as total thyroidectomy followed by radioiodine therapy and close follow-up of patients with minimally invasive type with vascular invasion and widely invasive type of FTC should be considered due to the chance of local recurrence and distant metastasis.
Methods: This retrospective study enrolled 91 patients diagnosed with FTC between November 1994 and October 2008. The clinicopathologic characteristics, treatment outcome and follow up data were analyzed.
Results: The median follow-up (f/u) period was 76.1 months. Distant metastases at the time of diagnosis were detected in 12 patients. During the f/u period, one local recurrence and 4 distant metastases developed. Local recurrence or distant metastasis were noticed in 12 out of 19 patients with widely invasive type and 5 out of 36 patients with minimally invasive type with vascular invasion were also noted. The median times to local recurrence or distant metastasis were 59.0 and 34.2 months, respectively. On analysis, according to the clinocopathologic factors, presence of vascular invasion, extrathyroidal extension, invasion to structure, incomplete excision and pathological classification were independent prognostic factors for recurrence or distant metastasis. Disease specific mortality was seen in one patient.
Conclusion: This study shows that aggressive treatments such as total thyroidectomy followed by radioiodine therapy and close follow-up of patients with minimally invasive type with vascular invasion and widely invasive type of FTC should be considered due to the chance of local recurrence and distant metastasis.
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REFERENCES
참고문헌 (16)
참고문헌 신청
1. [학술지(정기간행물)] - Hirokawa M / 2002 / Observer variation of encapsulated follicular lesions of the thyroid gland / Am J Surg Pathol 26 : 1508 ~ 1514
2. [학술지(정기간행물)] - Chan JK / 2002 / Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma / Am J Clin Pathol 117 : 16 ~ 18
3. [단행본] - Schneider AB / 1996 / Carcinoma of the follicular epithelium. In Werner and Ingbar's the Thyroid: a Fundamental and Clinical Text. / Lippincott-Raven : 902 ~ 943
4. [학술지(정기간행물)] - Emerick GT / 1993 / Diagnosis, treatment, and outcome of follicular thyroid carcinoma / Cancer 72 : 3287 ~ 3295
5. [학술지(정기간행물)] - D'Avanzo A / 2004 / Follicular thyroid carcinoma: histology and prognosis / Cancer 100 : 1123 ~ 1129
2. [학술지(정기간행물)] - Chan JK / 2002 / Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma / Am J Clin Pathol 117 : 16 ~ 18
3. [단행본] - Schneider AB / 1996 / Carcinoma of the follicular epithelium. In Werner and Ingbar's the Thyroid: a Fundamental and Clinical Text. / Lippincott-Raven : 902 ~ 943
4. [학술지(정기간행물)] - Emerick GT / 1993 / Diagnosis, treatment, and outcome of follicular thyroid carcinoma / Cancer 72 : 3287 ~ 3295
5. [학술지(정기간행물)] - D'Avanzo A / 2004 / Follicular thyroid carcinoma: histology and prognosis / Cancer 100 : 1123 ~ 1129
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UCI(KEPA) : I410-ECN-0101-2013-514-002679718