Risk Factors for Distant Metastasis in Patients with Follicular Thyroid Carcinoma

Min Kyu Sung; Yu-Mi Lee; Tae-Yon Sung; 윤종호; 정기욱; 홍석준

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자료유형: 학술저널

저자정보: Min Kyu Sung Yu-Mi Lee Tae-Yon Sung 윤종호 정기욱 홍석준

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제16권 제2호

발행연도: 2016.1

수록면: 25 - 30 (6page)

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Purpose: The major issue of follicular thyroid carcinoma (FTC) diagnosed after hemithyroidectomy is whether to undergo further treatments. The aim of this study is to examine the clinico-pathological characteristics of FTC and to evaluate the risk factors for distant metastasis. Methods: From 1993 to 2010, 274 patients underwent initial thyroid surgery and were subsequently diagnosed as FTC. After review of the histological sections by an experienced pathologist, 211 patients were confirmed as FTC and were enrolled in this study. Clinicopathological features were compared based on the presence or absence of distant metastases, and the risk factors for distant metastases and distant metastases-free survival (DMFS) rates were analyzed.Results: The patients included 39 males (18.5%) and 172 females (81.5%), with a mean age of 44.0±14.5 years. The median follow-up period was 99.5 months (range, 13.0∼222.0). Distant metastases were detected in 23 patients (10.9%), including 15 synchronous distant metastases and 8 metachronous distant metastases. In multivariate analysis, age ≥45 years, widely invasive FTC, tumor size ≥4.3 cm, and vascular invasion were independent risk factors for distant metastasis. DMFS rates in patients with these risk factors were significantly poorer than those in patients without these risk factors. Conclusion: Older age, aggressive histological classification, larger tumor size, and vascular invasion were independent risk factors for distant metastasis. FTC patients with these risk factors may be candidates for further treatments after diagnostic thyroid hemithyroidec-tomy.

#Follicular thyroid carcinoma #Distant metastasis #Risk factor #Survival rates

참고문헌 (14)

참고문헌 신청

DeLellis R / 2004 / WHO Classification of tumours. Pathology and genetics of tumours of endocrine organs / IARC Press :73~76

Lo CY / 2005 / Follicular thyroid carcinoma:the role of histology and staging systems in predicting survival / Ann Surg 242:708~715

Ito Y / 2007 / Prognosis and prognostic factors of follicular carcinoma in Japan: importance of postoperative pathological examination / World J Surg 31:1417~1424

Goffredo P / 2013 / Can minimally invasive follicular thyroid cancer be approached as a benign lesion?: a population-level analysis of survival among 1,200patients / Ann Surg Oncol 20:767~772

Sugino K / 2014 / Does completion thyroidectomy improve the outcome of patients with minimally invasive follicular carcinoma of the thyroid? / Ann Surg Oncol 21:2981~2986

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