지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.8
- 수록면
- 113 - 119 (7page)
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초록· 키워드
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Purpose: The prognosis of advanced gallbladder cancer remains unfortunate. Yet, the prognostic factors and the efficacy of extrahepatic bile duct resection remain unclear. The adequacy for extrahepatic bile duct resection for T2 gallbladder cancer, according to the characteristics of either the clinicopathological factors or the prognostic factors, was evaluated.
Methods: One hundred and one patients with gallbladder cancer underwent surgical resection at Yeungnam University Medical Center (YUMC) between January 2001 and July 2008. A retrospective analysis was conducted on 26 patients with pathologic stage T2.
Results: 7 of the 26 patients with T2 disease (26.9%) had lymph node metastasis. Of the 7 patients with lymph node metastasis, 3 patients underwent radical cholecystectomy (RC), and 4 patients underwent radical cholecystectomy combined with extrahepatic bile duct resection (RC＋BDR). The 1-year and 3-year survival rate of patients that underwent RC was 66.7% and 0% and patients that underwent RC＋BDR was 50.0% and 0%, respectively (P=0.433). Even with microscopic vascular invasion or perineural invasion, RC＋BDR did not provide any survival advantage compared with RC in T2 gallbladder cancer. Prognostic factors for patients with T2 gallbladder cancer was total bilirubin level, lymph node metastasis, differentiation of tumor, microscopic vascular invasion and perineural invasion.
Conclusion: For patients with T2 gallbladder cancer, RC is recommended, even with the presence of lymph node metastasis, microvascular invasion or perineural invasion. Resection of the extrahepatic bile duct is indicated for patients with T2 gallbladder cancer with involvement of the cystic duct or invasion of the hepatoduodenal ligament.
Methods: One hundred and one patients with gallbladder cancer underwent surgical resection at Yeungnam University Medical Center (YUMC) between January 2001 and July 2008. A retrospective analysis was conducted on 26 patients with pathologic stage T2.
Results: 7 of the 26 patients with T2 disease (26.9%) had lymph node metastasis. Of the 7 patients with lymph node metastasis, 3 patients underwent radical cholecystectomy (RC), and 4 patients underwent radical cholecystectomy combined with extrahepatic bile duct resection (RC＋BDR). The 1-year and 3-year survival rate of patients that underwent RC was 66.7% and 0% and patients that underwent RC＋BDR was 50.0% and 0%, respectively (P=0.433). Even with microscopic vascular invasion or perineural invasion, RC＋BDR did not provide any survival advantage compared with RC in T2 gallbladder cancer. Prognostic factors for patients with T2 gallbladder cancer was total bilirubin level, lymph node metastasis, differentiation of tumor, microscopic vascular invasion and perineural invasion.
Conclusion: For patients with T2 gallbladder cancer, RC is recommended, even with the presence of lymph node metastasis, microvascular invasion or perineural invasion. Resection of the extrahepatic bile duct is indicated for patients with T2 gallbladder cancer with involvement of the cystic duct or invasion of the hepatoduodenal ligament.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Jemal A / 2006 / Cancer statistics, 2006 / CA Cancer J Clin 56 : 106 ~ 130
2. [학술지(정기간행물)] - Baxter I / 1999 / Surgical palliation of carcinoma of the gallbladder / Hepatogastroenterology 46 : 1572 ~ 1577
3. [학술지(정기간행물)] - Lim SB / 1998 / A clinical study of prognostic factors in gallbladder cancer / J Korean Surg Soc 55 : 120 ~ 131
4. [학술지(정기간행물)] - Lee HS / 2002 / Gallbladder carcinoma diagnosed after laparoscopic cholecystectomy / Korean J Hepatobiliary Pancreat Surg 6 : 73 ~ 79
5. [학술지(정기간행물)] - Muratore A / 2000 / Radical surgery for gallbladder cancer: current options / Eur J Surg Oncol 26 : 438 ~ 443
2. [학술지(정기간행물)] - Baxter I / 1999 / Surgical palliation of carcinoma of the gallbladder / Hepatogastroenterology 46 : 1572 ~ 1577
3. [학술지(정기간행물)] - Lim SB / 1998 / A clinical study of prognostic factors in gallbladder cancer / J Korean Surg Soc 55 : 120 ~ 131
4. [학술지(정기간행물)] - Lee HS / 2002 / Gallbladder carcinoma diagnosed after laparoscopic cholecystectomy / Korean J Hepatobiliary Pancreat Surg 6 : 73 ~ 79
5. [학술지(정기간행물)] - Muratore A / 2000 / Radical surgery for gallbladder cancer: current options / Eur J Surg Oncol 26 : 438 ~ 443
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