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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 343 - 348 (6page)
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초록· 키워드
오류제보하기
In this study, antioxidant activity of methanol extract of Glycyrrhiza uralensis Fisch (GUE) against H<sub>2</sub>O<sub>2</sub>-induced DNA damage in human leucocytes and cell death in PC12 cells was determined. The effect of GUE on H<sub>2</sub>O<sub>2</sub>-induced DNA damage in human leucocytes was evaluated by the comet assay, where GUE (1-50 μg/mL) was a dose dependent inhibitor of DNA damage induced by H<sub>2</sub>O<sub>2</sub>. The protective effect of GUE against H<sub>2</sub>O<sub>2</sub>-induced damage on PC12 cells was investigated by MTT reduction assay and lactate dehydrogenase release assay. A marked reduction in cell survival induced by H<sub>2</sub>O<sub>2</sub> was significantly prevented by 1-50 μg/mL of GUE. The enzyme activity of caspase-3 was elevated in H<sub>2</sub>O<sub>2</sub>-treated PC12 cells, while preincubation with GUE for 30 min inhibited H<sub>2</sub>O<sub>2</sub>-induced caspase-3 activation in a dose-dependent manner. In conclusion, GUE ameliorates H<sub>2</sub>O<sub>2</sub>-induced DNA damage in human leucocytes and has neuroprotective effect by preventing cell death in PC 12 cell, suggesting that GU may be a potential candidate for novel therapeutic agents for neuronal diseases associated with oxidative stress.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Tang SY / 2004 / Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines / Free Radical Bio. Med 36 : 1575 ~ 1615
2. [학술지(정기간행물)] - Kim HY / 2001 / Isolation of antimicrobial substances from natural products and their preservative effect / Food Sci. Biotechnol 10 : 59 ~ 71
3. [단행본] - Wei F / 1999 / Food and medicines approved in China. In: Chinese Functional Food / New World Press : 111 ~ 112
4. [학술지(정기간행물)] - Wang ZY / 2001 / Licorice and cancer / Nutr. Cancer 39 : 1 ~ 11
5. [학술지(정기간행물)] - Fenwick GR / 1990 / Liquorice, Glycyrrhiza glabra L.: Composition, uses, and analysis / Food Chem 38 : 119 ~ 143
2. [학술지(정기간행물)] - Kim HY / 2001 / Isolation of antimicrobial substances from natural products and their preservative effect / Food Sci. Biotechnol 10 : 59 ~ 71
3. [단행본] - Wei F / 1999 / Food and medicines approved in China. In: Chinese Functional Food / New World Press : 111 ~ 112
4. [학술지(정기간행물)] - Wang ZY / 2001 / Licorice and cancer / Nutr. Cancer 39 : 1 ~ 11
5. [학술지(정기간행물)] - Fenwick GR / 1990 / Liquorice, Glycyrrhiza glabra L.: Composition, uses, and analysis / Food Chem 38 : 119 ~ 143
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UCI(KEPA) : I410-ECN-0101-2013-573-001015466