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논문 기본 정보

자료유형
학술저널
저자정보
Eu Jin Song (Pukyong National University) So Young Lee (Pukyong National University) Koth-Bong-Woo-Ri Kim (Pukyong National University) Jin Gyu Park (Korea Atomic Energy Research Institute) Jae Hun Kim (Korea Atomic Energy Research Institute) Ju Woon Lee (Korea Atomic Energy Research Institute) Myung Woo Byun (Korea Atomic Energy Research Institute) Dong Hyun Ahn (Pukyong National University)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 5
발행연도
2008.10
수록면
1,003 - 1,009 (7page)

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초록· 키워드

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This study was performed to determine the effects of γ-irradiation on the antiallergic activity of alginate. An alginate aqueous solution was γ-irradiated at 3, 5, 7, 10, 20, and 100 kGy. First, the molecular weight (Mw) of alginate rapidly decreased as the γ-irradiation dose increased up to 20 kGy. Then, the antiallergic activity of the γ-irradiated alginate was measured. Interlukin (IL)-4 cytokine and IgE level were significantly decreased in the γ-irradiated alginate groups as compared to the control group in vitro. The mice intraperitoneally administered with the γ-irradiated alginate exhibited lower ovalbumin-specific IgE and IgG1 level in serum than the control mice. Furthermore, the γ-irradiated alginate suppressed total and ovalbumin-specific IgE secretions in the splenocytes. Increased IL-2 level was observed in the culture supernatants of the splenocytes that were obtained from the mice administerd with the γ-irradiated alginate, while IL-4 level decreased. The present study indicates that γ-irradiated alginate can suppress allergy in a mouse allergy model.

목차

Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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