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논문 기본 정보

자료유형
학술저널
저자정보
Hyun-Kyung Kim (김천대학교) Li Li (인제대학교) Hyeong-Seon Lee (인제대학교) Mi-Ok Park (울산종합병원) Dinesh Bilehal (인제대학교) Wei Li (인제대학교) Yong-Ho Kim (인제대학교)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 18. no 5
발행연도
2009.10
수록면
1,186 - 1,192 (7page)

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초록· 키워드

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The purpose of this study was to evaluate the protective effects of Chlorella vulgaris extract (CVE) against carbon tetrachloride (CCl₄)-induced hepatotoxicity in mice. The mice received silymarin (100 ㎎/㎏), intragastrieally (i.g.) and CVE (50, 100, and 200 ㎎/㎏, i.g.), respectively, every other day, for 4 weeks before CCl₄ administration. Twenty-four hr after the administration of CCl₄, the serum and liver were analyzed. Our study found that in the CVE groups, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels had decreased significantly and the tissue injury was notably diminished compared to the CCl₄ group. The antioxidant activities of CVE groups, such as superoxide dismutase (SOD), catalase, and glutathione (GSH), were significantly increased and the activity of nitric oxide synthase (NOS) was remarkably increased in a CVE concentration-dependent manner. In the CVE groups, cytochrome P450 2B1/2B2 (CYP2B1/2) content was decreased. These results indicate that CVE has protective effects against CCl4-induced hepatotoxicity via stimulation of the antioxidant activity and nitric oxide (NO) production, and through inhibition of CYP2B1/2.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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