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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.2
- 수록면
- 203 - 207 (5page)
이용수
초록· 키워드
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The present study aimed at assessing the protective effect of water extract from fruit body of the Grifola frondosa (GFW) on carbon tetrachloride (CCl4)-induced hepatotoxicity. Rats orally administered with GFW 0.5, 1.0, 2.0 g/kg for 14 days were treated with CCl4 to induce hepatotoxicity. Pretreatment with GFW remarkably prevented the elevation of serum AST, ALT, ALP, LDH, γ-GTP, and liver lipid peroxides in CCl4-treated rat and GFW administration in liver injured rats by CCl₄ showed significant (p<0.05) protection of liver as evidenced from normal serum enzymes and malondialdehyde (MDA) levels. In the ultrastructural changes, administration of CCl₄damage of hepatocytes with vacuolation, a highly damaged endoplasmic reticulum, and degenerating nuclei. However, pre-administration with GFW preserved normal ultrastructure of hepatocytes. These results suggest that GFW had an effect to inhibit CCl₄-induced liver injury in rat, and that it could be used as an effective hepatoprotective agent against chemical-induced liver damage.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (35)
참고문헌 신청
1. [단행본] - Chang ST / 1989 / The nutritional attributes and medicinal value of edible mushrooms. In: Edible Mushrooms and Their Cultivation / CRC Press, Inc. : 27 ~ 40
2. [학술지(정기간행물)] - Breene WM / 1990 / Nutritional and medical value of specialty mushrooms / J. Food Protect 53 : 883 ~ 894
3. [학술지(정기간행물)] - Mizuno T / 1995 / Grifola frodosa: Pharmacological effects / Food Rev. Int 11 : 135 ~ 149
4. [학술지(정기간행물)] - Ohtsuru M / 1999 / Effects of administration of Grifola frondosa on blood pressure and body weight in spontaneously hypertensive rats. Nippon Shokuhin Kag / Kog. Kaishi 46 : 806 ~ 814
5. [학술지(정기간행물)] - Kurashige S / 1997 / Effects of Lentinus edodes, Grifola frondosa, and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine / Immunopharm. Immunot 19 : 175 ~ 183
2. [학술지(정기간행물)] - Breene WM / 1990 / Nutritional and medical value of specialty mushrooms / J. Food Protect 53 : 883 ~ 894
3. [학술지(정기간행물)] - Mizuno T / 1995 / Grifola frodosa: Pharmacological effects / Food Rev. Int 11 : 135 ~ 149
4. [학술지(정기간행물)] - Ohtsuru M / 1999 / Effects of administration of Grifola frondosa on blood pressure and body weight in spontaneously hypertensive rats. Nippon Shokuhin Kag / Kog. Kaishi 46 : 806 ~ 814
5. [학술지(정기간행물)] - Kurashige S / 1997 / Effects of Lentinus edodes, Grifola frondosa, and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine / Immunopharm. Immunot 19 : 175 ~ 183
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UCI(KEPA) : I410-ECN-0101-2013-573-001010214