지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Toll-like receptors (TLRs) induce innate immune responses that are essential for host defenses against invading microbial pathogens, thus leading to the activation of adaptive immune responses. In general, TLRs have two major downstream signaling pathways: the MyD88- and TRIF-dependent pathways, which lead to the activation of NF-<sub>κ</sub>and IRF3. Numerous studies have demonstrated that certain phytochemicals possessing anti-inflammatory effects inhibit NF-<sub>κ</sub>B activation induced by pro-inflammatory stimuli, including lipopolysaccharides and TNFα. However, the direct molecular targets for such anti-inflammatory phytochemicals have not been fully identified. Identifying the direct targets of phytochemicals within the TLR pathways is important because the activation of TLRs by pro-inflammatory stimuli can induce inflammatory responses that are the key etiological conditions in the development of many chronic inflammatory diseases. In this paper, we discuss the molecular targets of resveratrol, (-)-epigallocatechin-3-gallate (EGCG), and curcumin in the TLR signaling pathways. Resveratrol specifically inhibited the TRIF pathway in TLR3 and TLR4 signaling, by targetting TBK1 and RIP1 in the TRIF complex. Furthermore, EGCG suppressed the activation of IRF3 by targetting TBK1 in the TRIFdependent signaling pathways. In contrast, the molecular target of curcumin within the TLR signaling pathways is the receptor itself, in addition to IKKβ. Together, certain dietary phytochemicals can modulate TLR-derived signaling and inflammatory target gene expression, and in turn, alter susceptibility to microbial infection and chronic inflammatory diseases.
목차
Abstract
서론
Toll-like Receptor
Phytochemicals
결론
문헌
참고문헌 (68)
참고문헌 신청
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2. [학술지(정기간행물)] - Ulevitch RJ / 2004 / Therapeutics targeting the innate immune system 4 : 512 ~ 520
3. [학술지(정기간행물)] - Hoebe K / 2004 / The interface between innate and adaptive immunity 5 : 971 ~ 974
4. [학술지(정기간행물)] - Akira S / 2003 / Recognition of pathogen-associated molecular patterns by TLR family 85 : 85 ~ 95
5. [학술지(정기간행물)] - Liew FY / 2005 / Negative regulation of Toll-like receptor-mediated immune responses 5 : 446 ~ 458
2. [학술지(정기간행물)] - Ulevitch RJ / 2004 / Therapeutics targeting the innate immune system 4 : 512 ~ 520
3. [학술지(정기간행물)] - Hoebe K / 2004 / The interface between innate and adaptive immunity 5 : 971 ~ 974
4. [학술지(정기간행물)] - Akira S / 2003 / Recognition of pathogen-associated molecular patterns by TLR family 85 : 85 ~ 95
5. [학술지(정기간행물)] - Liew FY / 2005 / Negative regulation of Toll-like receptor-mediated immune responses 5 : 446 ~ 458
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UCI(KEPA) : I410-ECN-0101-2013-573-000862318