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Effect of Anti-atopic Allergic Reaction in Response to Oriental Herb Extracts
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생약재 추출물의 아토피 완화효과

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Type
Academic journal
Author
Hee-Jin Yang (성균관대학교) Kye Won Park (성균관대학교) Hyun-Suck Kim (성균바이오텍) Soo-Muk Cho (국립농업과학원) Ki-Moon Park (성균관대학교)
Journal
Korean Society of Food Science and Technology Korean journal of food science and technology Vol.42 No.1 KCI Accredited Journals SCOPUS
Published
2010.2
Pages
109 - 114 (6page)

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Effect of Anti-atopic Allergic Reaction in Response to Oriental Herb Extracts
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Research history (2)

2010

Effect of Anti-atopic Allergic Reaction in Response to Oriental Herb Extracts
Hee-Jin Yang ,  Kye Won Pa ,  k and others 4 Korean journal of food science and technology 2010.02 Academic journal

2008

[P8-167] Nc/Nga 마우스 모델을 이용한 생약추출물의 아토피 저감효과에 관한 연구
양희진 ,  조수묵 ,  방민혁 and others 2 한국식품영양과학회 학술대회발표집 2008.10 Proceeding
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Abstract· Keywords

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The in vivo and in vitro effects of oriental herb extracts of Cassia obtusifolia, Taraxacum platycarpum and Ulmusmacrocarpa on anti-atopic allergic reaction were evaluated in this study. A mixture of these extracts exhibited more potent anti-allergic activities in human mast cells than those from individual extracts. The herbal mixture significantly inhibited the release of compound 48/80-induced β-hexosaminidase release in the human mast cell line, HMC-1. The mixture also suppressed the production of PMA and A23187-induced inflammatory cytokines in HMC-1 cells. To further investigate the in vivo effects of the herbal mixture, a Dermatophagoides farinae (DF)-induced atopic dermatitis mouse model was utilized. Oral administration of the herbal mixture significantly decreased the ear thickness and swelling in DF treated NC/Nga mice in a dose dependent manner. Furthermore, serum levels of IgE and interleukin-4 (IL-4) were significantly decreased, whereas interferon-gamma (IFN-γ) levels were increased in the mixture administrated groups when compared to the control. Taken together, our data indicate the possibility of using a mixture of the oriental herb extract to relieve symptoms of atopic dermatitis.
#Cassia obtusifolia #Taraxacum platycarpum #Ulmus macrocarpa #anti-atopic allergic reaction

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References (28)

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1. [학술지(정기간행물)] - Na HJ / 2005 / Regulatory effect of atopic allergic reaction by Carpopeltis affinis / J. Ethnopharmacol. 101 : 43 ~ 48 google schola 2. [학술지(정기간행물)] - 최지훈 / 2007 / 음식물 히스타민 함량에 관한 한국에서의 연구 / 대한피부과학회지 45 (8) : 768 ~ 771 google schola 3. [학술지(정기간행물)] - 장호선 / 2002 / 아토피 피부염의 진단과 치료 / 가정의학회지 23 (7) : 2 ~ 840 dbpia 4. [학술대회논문] - Taylor ML / 2001 / Mast cells in allergy and host defense / Allergy Asthma Proc. : 115 ~ 119 google schola 5. [학술지(정기간행물)] - 이지현 / 2006 / 아토피피부염학회 보고서: 한국 아토피피부염의 치료지침 / 대한피부과학회지 44 (8) : 907 ~ 913 google schola

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