지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.16 No.3
- 발행연도
- 2011.9
- 수록면
- 242 - 247 (6page)
이용수
초록· 키워드
오류제보하기
The methanolic extract of Rosa davurica Pall. roots exhibited strong antioxidant activity in a 1,1-diphenyl-2- picryl-hydrazyl (DPPH) radical scavenging assay and was found to be a dose-dependent inhibitor of non-enzymatic formation of advanced glycation end products (AGEs), which are relevant to diabetes complications. HPLC-diode array detector (DAD) analysis of the R. davurica Pall. root extract led to the identification of four compounds: hydrocaffeic acid, catechin, epicatechin, and ellagic acid. Catechin was present in the largest amount and exhibited high antiglycation activity. A CYP3A4 assay was used to investigate potential interactions between drugs and the extract, and results suggest that the R. davurica Pall. root extract had moderate potential for interfering with drug metabolism. The R. davurica Pall. extract did not display anti-inflammatory activity on the level of that for tumor necrosis factor-α (TNF-α) in a lipopolysaccharide (LPS)-stimulated macrophage assay; however, the extract did exhibit low to moderate immunostimulatory activity in a pro-inflammatory macrophage assay. Therefore, we conclude that R. davurica Pall. root is a promising anti-AGE agent with low to moderate risks of associated inflammation or drug interaction.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (16)
참고문헌 신청
1. [단행본] - An DK / 1998 / Illustrated book of Korean medicinal herbs. 6th edition / Kyo-Hack Publishing Co : 374 ~
2. [학술지(정기간행물)] - Yoshida T / 1989 / Taxifolin apioside and davuriciin M1, a hydrolysable tannin from Rosa davurica / Phytochemistry 28 : 2177 ~ 2181
3. [학술지(정기간행물)] - 류동영 / 200306 / Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1 1-diphenyl-2-picrylhydrazyl radical / PHYTOMEDICINE 10 (6-7) : 544 ~ 551
4. [학술지(정기간행물)] - Sheetz MJ / 2002 / Molecular understanding of hyperglycemia's adverse effects for diabetic complications / Jama 288 : 2579 ~ 2588
5. [학술지(정기간행물)] - Farsi DA / 2007 / Inhibition of non-enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize (Zea mays) / Phytother Res 22 : 108 ~ 112
2. [학술지(정기간행물)] - Yoshida T / 1989 / Taxifolin apioside and davuriciin M1, a hydrolysable tannin from Rosa davurica / Phytochemistry 28 : 2177 ~ 2181
3. [학술지(정기간행물)] - 류동영 / 200306 / Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1 1-diphenyl-2-picrylhydrazyl radical / PHYTOMEDICINE 10 (6-7) : 544 ~ 551
4. [학술지(정기간행물)] - Sheetz MJ / 2002 / Molecular understanding of hyperglycemia's adverse effects for diabetic complications / Jama 288 : 2579 ~ 2588
5. [학술지(정기간행물)] - Farsi DA / 2007 / Inhibition of non-enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize (Zea mays) / Phytother Res 22 : 108 ~ 112
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UCI(KEPA) : I410-ECN-0101-2013-511-000751794