지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
There has been no genome-wide association study (GWAS) for macronutrient intake as a quantitative trait. To explore genetic loci associated with total calorie and macronutrient intake, genome-wide association data of autosomal single nucleotide polymorphisms (SNPs) from Korean adults were analyzed. We conducted a GWAS in 3,690 men and women aged 40 to 60 years from an urban population-based cohort. At the baseline examination (June 18, 2001 through January 29, 2003), DNA samples of the study subjects were collected and analyzed for genotyping. The information of average daily consumption of total calorie, carbohydrate, protein, and fat was obtained from a semi-quantitative food frequency questionnaire and transformed by natural logarithm for analyses after adjustment of calorie intake. Using multivariate linear regression analysis adjusted for age, sex, and height, we tested for 352,021 SNPs and found weak associations, which do not reach genome-wide association significance, with calorie and macronutrient intake. However, a number of SNPs were found to have potential associations with macronutrient intake; in particular, signals in SORBS1 and those in PRKCB1 were likely associated with carbohydrate and fat intake, respectively. We observed an inverse association between the minor allele of the SNPs in these genes and the amount of consumption of carbohydrate or fat. Our GWAS identified loci and minor alleles weakly associated with macronutrient intake. Because SORBS1 and PRKCB1 are reportedly associated with the metabolism of glucose and lipid as well as with obesity-related diseases, further investigations on biological and functional roles of polymorphism of these genes in the relation to macronutrient intake are warranted.
목차
ABSTRACT
서론
연구방법
결과
고찰
요약 및 결론
Literature cited
참고문헌 (1)
참고문헌 신청
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
수면시간과 비만, 열량영양소 섭취비율 및 신체 활동량과의 관련성
대한지역사회영양학회지
2011 .06
-
한국인의 대사증후군과 다량 영양소의 섭취패턴
한국영양학회지
2011 .04
-
청소년기의 열량영양소 섭취 양상과 혈압 ( Macronutrient Intake and Blood Pressure of Adolescents in Rural Korean )
대한지역사회영양학회지
1996 .11
-
대학생의 영양섭취 실태에 관한 연구
대한가정학회지
1994 .01
-
Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
Genomics & informatics
2011 .01
-
550,000 tag SNP markers for Genome-wide association studies
한국유전체학회 Conference
2006 .01
-
Effect of plate size on meal energy intake in normal weight women
Nutrition Research and Practice
2016 .10
-
Effect of plate size on meal energy intake in normal weight women
Nutrition Research and Practice
2016 .10
-
Dietary Reference Intakes for Energy and Physical Activity
Nutritional Sciences
2004 .11
-
Dietary intakes and obesity of Malaysian adults
Nutrition Research and Practice
2019 .04
-
Dietary intakes and obesity of Malaysian adults
Nutrition Research and Practice
2019 .04
-
월경주기동안의 여대생의 열량섭취와 열량구성비 ( Energy and Macronutrient Intakes during Menstrual Cycle in Young Women )
대한지역사회영양학회지
1998 .05
-
경북 농촌지역 60세 이상 성인 및 노인의 열량영양소 및 무기질, 비타민 섭취조사
한국영양학회지
2003 .12
-
Characterization of Single Nucleotide Polymorphisms in 55 Disease-Associated Genes in a Korean Population
Genomics & informatics
2007 .01
-
강화지역 청소년의 열량영양소 섭취유형과 지방조직의 체내분포와의 관련성 ( Macronutrient Consumption Pattern in Relation to Regional Body Fat Distribution in Korean Adolescents )
대한지역사회영양학회지
1999 .06
-
3대 열량소를 스스로 선택하게 했을 때 흰쥐의 식이 선택성향 및 저전류 Stress가 이에 미치는 영향
한국영양학회지
1990 .12
-
Total energy intake according to the level of skeletal muscle mass in Korean adults aged 30 years and older : an analysis of the Korean National Health and Nutrition Examination Surveys (KNHANES) 2008-2011
Nutrition Research and Practice
2018 .06
-
Total energy intake according to the level of skeletal muscle mass in Korean adults aged 30 years and older : an analysis of the Korean National Health and Nutrition Examination Surveys (KNHANES) 2008-2011
Nutrition Research and Practice
2018 .06
-
Adjusting sampling bias in case-control genetic association studies
한국데이터정보과학회지
2014 .10
-
남해도 지역이 임신후반기 임부의 영양실태 조사
대한가정학회지
1982 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Temperate Japonica 품종의 카드뮴 함량에 관한 전장유전체연관분석
이상범
,
김원일
,
박용진
외 3명
한국토양비료학회 학술발표회 초록집
2016
.03
생존시간과 연관된 유전자 간의 교호작용에 관한 다중차원축소방법의 확장
오진석
,
이승연
한국데이터정보과학회지
2014
.10
더미 다중인자 차원축소법에 의한 검 증력과 주요 유전자 규명
여정수
,
라부미
,
이호근
외 2명
한국데이터정보과학회지
2013
.04
식품과 영양에서 유전체학의 중요성 및 응용
엄수종
식품과학과 산업
2002
.03
일제강점기 한국의 혁명 담론 : 3.1운동과 그 전후
변성호
한국동양정치사상사연구
2024
.03
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2012-594-004191608