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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.10
- 수록면
- 1,127 - 1,135 (9page)
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Genome-wide association studies (GWAS) are designed to discover genetic vari-ants such as single nucleotide polymorphisms (SNPs) that are associated with human complex traits. Although there is an increasing interest in the application of GWAS methodologies to population-based cohorts, many published GWAS have adopted a case-control design, which raise an issue related to a sampling bias of both case and control samples. Because of unequal selection probabilities between cases and controls, the samples are not representative of the population that they are purported to represent. Therefore, non-random sampling in case-control study can potentially lead to inconsistent and biased estimates of SNP-trait associations. In this paper, we pro-posed inverse-probability of sampling weights based on disease prevalence to eliminate a case-control sampling bias in estimation and testing for association between SNPs and quantitative traits. We apply the proposed method to a data from the Korea Asso-ciation Resource project and show that the standard estimators applied to the weighted data yield unbiased estimates.
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참고문헌 (7)
참고문헌 신청
1. [학술지(정기간행물)] - Cho, Y. S. / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors in uencing eight quantitative traits / Nature Genetics 41 : 527 ~ 534
2. [학술지(정기간행물)] - Hernan, M. A. / 2006 / Estimating causal e ects from epidemiological data / Journal of Epidemiology and Community Health 60 : 578 ~ 586
3. [학술지(정기간행물)] - Hunter, D. J. / 2007 / A genome-wide association study identi es alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer / Nature Genetics 39 : 870 ~ 874
4. [학술지(정기간행물)] - Manolio, T. A. / 2009 / Finding the missing heritability of complex diseases / Nature Genetics 461 : 747 ~ 753
5. [학술지(정기간행물)] - Scott, L. J. / 2007 / A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants / Science 316 : 1341 ~ 1345
2. [학술지(정기간행물)] - Hernan, M. A. / 2006 / Estimating causal e ects from epidemiological data / Journal of Epidemiology and Community Health 60 : 578 ~ 586
3. [학술지(정기간행물)] - Hunter, D. J. / 2007 / A genome-wide association study identi es alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer / Nature Genetics 39 : 870 ~ 874
4. [학술지(정기간행물)] - Manolio, T. A. / 2009 / Finding the missing heritability of complex diseases / Nature Genetics 461 : 747 ~ 753
5. [학술지(정기간행물)] - Scott, L. J. / 2007 / A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants / Science 316 : 1341 ~ 1345
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UCI(KEPA) : I410-ECN-0101-2018-041-001375479