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Effects of d-α-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model
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Type
Academic journal
Author
Do Yeon Kim (Kyung Hee University) Jinkyung Kim (Kyung Hee University) Hye Jin Ham (Kyung Hee University) Ryowon Choue (Kyung Hee University)
Journal
The Korean Nutrition Society Nutrition Research and Practice Vol.7 No.6 KCI Accredited Journals SCIE
Published
2013.12
Pages
481 - 487 (7page)

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Effects of d-α-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model
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High-fat diet up-regulates either insulin resistance or triglycerides, which is assumed to be related to the expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ. The beneficial effects of vitamin E on insulin resistance are well known; however, it is not clear if vitamin E with a high-fat diet alters the expression of PPAR-α and PPAR-γ. We investigated the effects of d-α-tocopherol supplementation on insulin sensitivity, blood lipid profiles, lipid peroxidation, and the expression of PPAR-α and PPAR-γ in a high-fat (HF) diet-fed male C57BL/6J model of insulin resistance. The animals were given a regular diet (CON; 10% fat), a HF diet containing 45% fat, or a HF diet plus d-α-tocopherol (HF-E) for a period of 20 weeks. The results showed that the HF diet induced insulin resistance and altered the lipid profile, specifically the triglyceride (TG) and total cholesterol (TC) levels (P < 0.05). In this animal model, supplementation with d-α-tocopherol improved insulin resistance as well as the serum levels of TG and very-low-density lipoprotein-cholesterol (VLDL-C) (P < 0.05). Moreover, the treatment decreased the levels of malondialdehyde (MDA) in the serum and liver while increasing hepatic PPAR-α expression and decreasing PPAR-γ expression. In conclusion, the oral administration of d-α-tocopherol with a high-fat diet had positive effects on insulin resistance, lipid profiles, and oxidative stress through the expression of PPAR-α and PPAR-γ in a high-fat diet-fed male mice.
#High fat diet #supplementation #d-α-tocopherol #insulin resistance

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