지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 207 - 212 (6page)
이용수
초록· 키워드
오류제보하기
Archivillin, a muscle-specific isoform of supervillin, is a component of the costameric cytoskeleton of muscle cells. The purpose of this study was to determine which protein in the skeletal muscle collaborates with archvillin C-terminus. For this purpose, a yeast two-hybrid screening of human skeletal muscle cDNA library was performed using the C-terminal region of archvillin as bait. This study shows that seven human skeletal muscle proteins, namely, nebulin, xeplin, archvillin, GAPDH, TOX4, PITRM1, and YME1L1 interact with archvillin C-terminus. Especially, xeplin is a newly discovered protein interacts with archvillin C-terminus. These results indicate that archvillin C-terminus acts as a bridge between nebulin and xeplin at costameres. Archvillin C-terminal region interacts with nebulin C-terminal region at Z-discs and interacts with xeplin at the vicinity of sarcolemma. I propose that these interactions may contribute to formation of costameric structure and muscle contraction.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (13)
참고문헌 신청
1. [학술지(정기간행물)] - Anastasi G / 2008 / Costameric proteins in human skeletal muscle during muscular inactivity / J Anat 213 : 284 ~ 295
2. [학술지(정기간행물)] - Bang ML / 2002 / Molecular dissection of the interaction of desmin with the C-terminal region of nebulin / J Struct Bi 137 : 119 ~ 127
3. [학술지(정기간행물)] - Clark KA / 2002 / Striated muscle cytoarchitecture: an intricate web of form and function / Annu Rev Cell Dev Biol 18 : 637 ~ 706
4. [학술지(정기간행물)] - Craig SW / 1983 / Gamma actin, spectrin, and intermediate filament proteins colocalize with vinculin at costameres, myofibril-to-sarcolemma attachment sites / Cell Motil 3 : 449 ~ 462
5. [학술지(정기간행물)] - Gregorio GV / 2003 / Mimicry between the hepatitis C virus polyprotein and antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis C virus infection / Clin Exp Immunol 133 : 404 ~ 413
2. [학술지(정기간행물)] - Bang ML / 2002 / Molecular dissection of the interaction of desmin with the C-terminal region of nebulin / J Struct Bi 137 : 119 ~ 127
3. [학술지(정기간행물)] - Clark KA / 2002 / Striated muscle cytoarchitecture: an intricate web of form and function / Annu Rev Cell Dev Biol 18 : 637 ~ 706
4. [학술지(정기간행물)] - Craig SW / 1983 / Gamma actin, spectrin, and intermediate filament proteins colocalize with vinculin at costameres, myofibril-to-sarcolemma attachment sites / Cell Motil 3 : 449 ~ 462
5. [학술지(정기간행물)] - Gregorio GV / 2003 / Mimicry between the hepatitis C virus polyprotein and antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis C virus infection / Clin Exp Immunol 133 : 404 ~ 413
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UCI(KEPA) : I410-ECN-0101-2012-510-004137175