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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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In order to evaluate estrogenic compounds in brown algae, an in vitro test system for the verification of estrogenic activity was applied. Fractions from ethanol extracts of each brown alga were prepared by a systematic fractionation procedure with solvents such as H₂O, hexane, butanol and methanol. Aqueous fractions of brown algae showed the highest estrogenic activities. Estrogenic activities of 500 ㎍/㎖ aqueous fractions of Undaria pinnatifida and Laminaria japonica showed almost the same strength as that of 10?? M standard solution (17β-estradiol). Furthermore, estrogenic activities of 500 ㎍/㎖ aqueous fractions of Ecklonia stolonifera and Porphyra suborbiculate represented higher activities than that of 10?? M 17β-estradiol. These observations suggest that aqueous fractions of all these brown algae are expected to possess estrogenic compounds and could be developed as estrogenic agents for postmenopausal disorder.
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참고문헌 (15)
참고문헌 신청
2. [학술지(정기간행물)] - Cho, K. J. / 1990 / Antitumor effect and immunology activity of seaweeds toward Sarcoma-1 / J. Korean Soc. Food Sci. Nutr 23 : 345 ~ 352
3. [학술지(정기간행물)] - Gaido, K. W. / 1999 / Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta / J. Endocrinol 140 : 5746 ~ 5753
4. [학술지(정기간행물)] - Gronen, S. / 1999 / Serum vitellogenin levels and reproductive impairment of male Japanese Medaka exposed to 4-tert-octylphenol / Environ. Health Perspect 107 : 385 ~ 390
6. [학술지(정기간행물)] - Heikkinen, J. / 2000 / Long-term continuous combined hormone replacement therapy in the prevention of postmenopausal bone loss: a comparison of high- and low-dose estrogen-progestin regimens / Int. Osteoporosis 11 : 929 ~ 937
7. [학술지(정기간행물)] - Jang, M. K. / 2008 / Evaluation of estrogenic activities of natural products / J. Clin Biochem. Nutri 43 : 145 ~ 148
3. [학술지(정기간행물)] - Gaido, K. W. / 1999 / Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta / J. Endocrinol 140 : 5746 ~ 5753
4. [학술지(정기간행물)] - Gronen, S. / 1999 / Serum vitellogenin levels and reproductive impairment of male Japanese Medaka exposed to 4-tert-octylphenol / Environ. Health Perspect 107 : 385 ~ 390
6. [학술지(정기간행물)] - Heikkinen, J. / 2000 / Long-term continuous combined hormone replacement therapy in the prevention of postmenopausal bone loss: a comparison of high- and low-dose estrogen-progestin regimens / Int. Osteoporosis 11 : 929 ~ 937
7. [학술지(정기간행물)] - Jang, M. K. / 2008 / Evaluation of estrogenic activities of natural products / J. Clin Biochem. Nutri 43 : 145 ~ 148
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UCI(KEPA) : I410-ECN-0101-2012-470-004162988