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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국원예학회 HORTICULTURE ENVIRONMENT and BIOTECHNOLOGY HORTICULTURE ENVIRONMENT and BIOTECHNOLOGY Vol.51 No.6
- 발행연도
- 2010.12
- 수록면
- 580 - 587 (8page)
이용수
초록· 키워드
오류제보하기
The effects of Cuscuta japonica BuOH fraction (CJBF) on the proliferation of human hair dermal papilla cells (HHDPCs) and on the stimulation of hair growth in a cyclophosphamide (CYP)-induced alopecia model C57BL/6 mouse were studied. In cell-based MTT assay, the proliferation rates were increased 25% in CJBF treated group of CYP-treated HHDPCs. Gene expression-based RT-PCR study was conducted to find the mechanism. The ratio of Bcl-2/Bax gene expression was increased 195% in CJBF treated group onto CYP-treated HHDPCs. In CYP-induced alopecia model C57BL/6 mouse study, promotion of hair growth was observed in the mouse groups treated with the CJBF and CYP-injection. Tissue histological analysis showed the number of hair follicles and the thickness of the epidermis were increased in the CJBF treated groups. Also, to find the possible mechanism, western blot assay was adopted for the tissues of CJBF treated mouse group. Anti-apoptotic Bcl-2 proteins were increased, and pro-apoptotic Bax proteins were decreased by 329%. The results led the conclusion that CJBF promotes hair growth and retards the catagen phase in HHDPCs and C57BL/6 mouse model. Therefore CJBF might be a potential new therapeutic source for the prevention of hair loss.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
Literature Cited
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Adams, J.M. / 1998 / The Bcl-2 protein family: arbiters of cell survival / Sci 281 : 1322 ~ 1326
2. [단행본] - Ahn, D.K. / 1998 / Illustrated book of Korean medicinal herbs / Kyo-Hak Publishing Co.
3. [학술지(정기간행물)] - Botchkarev, V.A. / 2000 / p53 is essential for chemotherapy-induced hair loss / Cancer Res 60 : 5002 ~ 5006
4. [학술지(정기간행물)] - Botchkareva, N.V. / 2006 / Apoptosis in the Hair Follicle / J. Invest. Dermatol 126 : 258 ~ 264
5. [학술지(정기간행물)] - Foitzik, K. / 2007 / LCarnitine–L-tartrate promotes human hair growth in vitro / Exp. Dermatol 16 : 936 ~ 945
2. [단행본] - Ahn, D.K. / 1998 / Illustrated book of Korean medicinal herbs / Kyo-Hak Publishing Co.
3. [학술지(정기간행물)] - Botchkarev, V.A. / 2000 / p53 is essential for chemotherapy-induced hair loss / Cancer Res 60 : 5002 ~ 5006
4. [학술지(정기간행물)] - Botchkareva, N.V. / 2006 / Apoptosis in the Hair Follicle / J. Invest. Dermatol 126 : 258 ~ 264
5. [학술지(정기간행물)] - Foitzik, K. / 2007 / LCarnitine–L-tartrate promotes human hair growth in vitro / Exp. Dermatol 16 : 936 ~ 945
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UCI(KEPA) : I410-ECN-0101-2012-525-003764542