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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 225 - 232 (8page)
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초록· 키워드
오류제보하기
Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as well as increased spontaneous activity following spinal cord injury, which often called hyperexcitability or central sensitization. Under hyperexcitable states, spinal neurons lose their ability of discrimination and encoding somatosensory information followed by abnormal somatosensory recognition to non-noxious and noxious stimuli. In the present review, we summarize a variety of pathophysiological mechanisms of neuronal hyperexcitability for treating or preventing central neuropathic pain syndrome following spinal cord injury.
목차
척수손상에 의한 중추신경병증성 통증의 분류
감각신호 전달 기전
신경세포 과흥분성의 유발 기전
척수 후각 신경세포의 비정상적인 흥분성
결론
감사의 글
참고문헌
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Bennett, A.D. / 2000 / Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury / Brain Res 859 : 72 ~ 82
2. [학술지(정기간행물)] - Brambilla, R. / 2009 / Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury / J. Neurochem. 110 : 765 ~ 778
3. [학술지(정기간행물)] - Carlton, S.M. / 2009 / Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury / Pain 147 : 265 ~ 276
4. [학술지(정기간행물)] - Christensen, M.D. / 1997 / Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat / Exp. Neurol. 147 : 463 ~ 475
5. [학술지(정기간행물)] - Chu, K.L. / 2004 / Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury:implications for mechanical sensitivity / Neurosci. Lett. 372 : 123 ~ 126
2. [학술지(정기간행물)] - Brambilla, R. / 2009 / Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury / J. Neurochem. 110 : 765 ~ 778
3. [학술지(정기간행물)] - Carlton, S.M. / 2009 / Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury / Pain 147 : 265 ~ 276
4. [학술지(정기간행물)] - Christensen, M.D. / 1997 / Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat / Exp. Neurol. 147 : 463 ~ 475
5. [학술지(정기간행물)] - Chu, K.L. / 2004 / Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury:implications for mechanical sensitivity / Neurosci. Lett. 372 : 123 ~ 126
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UCI(KEPA) : I410-ECN-0101-2012-510-003686408