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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.14 No.3
- 발행연도
- 2009.9
- 수록면
- 201 - 207 (7page)
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초록· 키워드
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In an effort to improve ginsenoside bioavailability, the ginsenosides of fermented red ginseng were examined with respect to bioavailability and physiological activity. The results showed that the fermented red ginseng (FRG) had a high level of ginsenoside metabolites. The total ginsenoside contents in non-fermented red ginseng (NFRG) and FRG were 35715.2 ㎍/mL and 34822.9 ㎍/mL, respectively. However, RFG had a higher content (14914.3 ㎍/mL) of ginsenoside metabolites (Rg3, Rg5, Rk1, CK, Rh1, F2, and Rg2) compared to NFRG (5697.9 ㎍/mL). The skin permeability of RFG was higher than that of NFRG using Franz diffusion cells. Particularly, after 5 hr, the skin permeability of RFG was significantly (p＜0.05) higher than that of NFRG. Using everted instestinal sacs of rats, RFG showed a high transport level (10.3 ㎎ of polyphenols/g sac) compared to NFRG (6.67 of ㎎ of polyphenols/g sac) after 1 hr. After oral administration of NFRG and FRG to rats, serum concentrations were determined by HPLC. Peak concentrations of Rk1, Rh1, Rc, and Rg5 were approximately 1.64, 2.35, 1.13, and 1.25-fold higher, respectively, for FRG than for NFRG. Furthermore, Rk1, Rh1, and Rg5 increased more rapidly in the blood by the oral administration of FRG versus NFRG. FRG had dramatically improved bioavailability compared to NFRG as indicated by skin permeation, intestinal permeability, and ginsenoside levels in the blood. The significantly greater bioavailability of FRG may have been due to the transformation of its ginsenosides by fermentation to more easily absorbable forms (ginsenoside metabolites).
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Park JH / 2004 / Sun ginseng-a new processed ginseng with fortified activity / Food Ind Nutr : 23 ~ 27
2. [학술지(정기간행물)] - Kitagawa I / 1983 / Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra / Yakugaku Zasshi : 612 ~ 622
3. [학술지(정기간행물)] - Wu JY / 1992 / Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine / J Immunol : 1519 ~ 1525
4. [학술지(정기간행물)] - Mochizuki M / 1995 / Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)- and 20(S)-ginsenoside Rg3, of red ginseng / Biol Pharm Bull : 1197 ~ 1202
5. [학술지(정기간행물)] - Sato K / 1994 / Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng-ginsenoside Rb2 / Biol Pharm Bull : 635 ~ 639
2. [학술지(정기간행물)] - Kitagawa I / 1983 / Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra / Yakugaku Zasshi : 612 ~ 622
3. [학술지(정기간행물)] - Wu JY / 1992 / Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine / J Immunol : 1519 ~ 1525
4. [학술지(정기간행물)] - Mochizuki M / 1995 / Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)- and 20(S)-ginsenoside Rg3, of red ginseng / Biol Pharm Bull : 1197 ~ 1202
5. [학술지(정기간행물)] - Sato K / 1994 / Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng-ginsenoside Rb2 / Biol Pharm Bull : 635 ~ 639
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UCI(KEPA) : I410-ECN-0101-2009-511-018845677