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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 113 - 118 (6page)
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Cell death induced by menadione (vitamin K-3,2-methyl-1,4-naphthoquinone) has been investigated in human promyelocytic leukemia HL-60 cells. Menadione was found to induce both apoptosis and necrosis in HL-60 cells. Low concentration (1~50 μM) of menadione induced apoptotic cell death, which was demonstrated by typical DNA ladder patterns on agarose gel electrophoresis and flow cytometry analysis. In contrast, a high concentration of menadione (100 μM) induced necrotic cell death, which was demonstrated by DNA smear pattern in agarose gel electrophoresis. Necrotic cell death was accompanied with a great reduction of cell viability. Menadione activated caspase-3, as evidenced by both increased protease activity and proteolytic cleavage of 116 kDa poly(ADP-ribose) polymerase (PARP) into 85 kDa cleavage product. Caspase-3 activity was maximum at 50 μM of menadione, and very low at 100 μM of menadione. Taken together, our results showed that menadione induced mixed types of cell death, apoptosis at low concentrations and necrosis at high concentrations in HL-60 cells.
목차
INTRODUCTION
METARIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Menadione-induced Cytotoxicity in Rat Platelets: Absence of the Detoxifying Enzyme, Quinone Reductase
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1995 .01
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Menadione 의 대사체인 Menadione - Glutathione conjugate ( men-sg ) 가 흰쥐 혈소판에 미치는 세포독성의 평가 및 men - sg 의 안정성에 관한 연구 ( evaluation of cytotoxicity to rut platelets by menadione - glutathione conjugate and its stability in biological assay system )
한국독성학회지
1995 .06
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Effects of Red Ginseng Total Saponin on Menadione-induced Hepatotoxicity in the Rat
한국실험동물학회 학술발표대회 논문집
1998 .04
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Important Role of Glutathione in Protecting Against Menadione-Induced Cytotoxicity in Rat Platelets
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
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메나디온에 의한 혈소판 내 칼슘 변화측정시 형광 색소 사용의 문제점
약학회지
1997 .01
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menadione 과 plasma 내의 protein thiol 의 비효소적인 화학반응에 의한 활성산소 생성 ( Generation of Reactive Oxygen Speies by Moenzymatic Reaction of Menadione With Protein Thiols in Plasma )
한국독성학회지
1997 .09
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The Role of Rat Plasma in Manifesting Toxicity of Erythrocytes by Water-Soluble Menadione: Further Evidence of Free Radical Generation
대한약학회 학술대회
2000 .01
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백혈병 세포주 HL-60에서 과루실 세포고사 유도 효과
동의생리병리학회지
2005 .01
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Quinones ( Menadione , Benzoquinone , 및 2 , 3 - Dimethoxy - 1 , 4 - naphthoquinone ) 의 혈소판 세포독성 ( Effects of Various Quinones ( Menadione , Benzoquinone and 2 , 3-Dimethoxy-1 , 4-naphthoquinone ) on Rat Platelets )
한국독성학회지
1996 .06
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백혈병 세포주 HL-60에서 과루실(瓜蔞實)의 세포고사 유도 효과
한국전통의학지
2006 .01
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Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with MitochondrialDysfunction
Cancer Research and Treatment
2002 .01
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Induction of the apoptosis of HL -60 leukemia cells by Scytosiphon lomentaria
한국응용약물학회 추계학술발표논문집
2003 .01
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혈액암 세포에서 부자(附子) 추출물의 Apoptosis 유도 효과
동의생리병리학회지
2005 .01
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Cell Cycle, Cell Death and Apoptosis
대한핵의학회 연수교육
2002 .01
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Caspase-dependent apoptosis by naphthoquinone analog in HL-60 cells
대한약학회 학술대회
2001 .01
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Differential Effects of Superoxide Radical on the Action Potentials in Ventricular Muscles, Purkinje Fibers and Atrial Muscles in the Heart of Different Aged Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
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감마방사선에 의한 암세포의 세포손상에 관한 연구
대한방사선협회지
2004 .01
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A Natural Product, Chios Gum Mastic, Induces the Death of HL-60 Cells via Apoptosis and Cell Cycle Arrest
International Journal of Oral Biology
2011 .01
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UCI(KEPA) : I410-ECN-0101-2009-513-018638834