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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제19권 제1호
- 발행연도
- 1996.1
- 수록면
- 12 - 17 (6page)
이용수
초록· 키워드
오류제보하기
Our previous studies demonstrate that menadione (MEN) is cytotoxic to platelets of rats by depleting glutathione (GSH). In order to clarify whether GSH has a role in protecting against menadione-induced cytotoxicity, the effect of GSH depletors as well as GSH precusors on menadione-induced cytotoxicity was investigated. Cysteine and dithiothreitol (DTT) prevent MEN-induced cytotoxicity in a dose-dependent manner, as determined by LDH leakage and change in turbidity. When platelets were treated with 1-chloro-2,4-dinitrobenzene (CDNB) and diethylmaleate (DEM), both of which deplete intracellular GSH, MEN-induced cytotoxicity was potentiated in the CDNB-treated paltelets, but not in the DEM-treated platelets. These data suggest that the GSH in platelets plays an important role in protecting against cytotoxicity induced by menadione.
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Menadione-induced Cytotoxicity in Rat Platelets: Absence of the Detoxifying Enzyme, Quinone Reductase
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1995 .01
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Menadione 의 대사체인 Menadione - Glutathione conjugate ( men-sg ) 가 흰쥐 혈소판에 미치는 세포독성의 평가 및 men - sg 의 안정성에 관한 연구 ( evaluation of cytotoxicity to rut platelets by menadione - glutathione conjugate and its stability in biological assay system )
한국독성학회지
1995 .06
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메나디온에 의한 혈소판 내 칼슘 변화측정시 형광 색소 사용의 문제점
약학회지
1997 .01
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Apoptosis Induction by Menadione in Human Promyelocytic Leukemia HL-60 Cells
Toxicological Research
2009 .09
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Chemical-Induced Cytotoxicity in Platelet Rich Plasma Isolated from Rats
한국독성학회지
1997 .09
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Anti-aggregation of platelets by quinones is associated with their cytotoxicity to platelets
한국보건교육건강증진학회 학술대회 발표논문집
1999 .10
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Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Effects of Red Ginseng Total Saponin on Menadione-induced Hepatotoxicity in the Rat
한국실험동물학회 학술발표대회 논문집
1998 .04
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The Roles of Atp and Calcium in Morphology Changes and Cytotoxicity Induced by Benzoquinone in Platelets
대한약학회 학술대회
2001 .01
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The Roles of ATP and Calcium in Morphology Changes and Cytotoxicity Induced by Benzoquinone in Platelets
대한약학회 학술대회
2000 .01
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Effectiveness of Platelet Function Analyzer-100 for Laboratory Detection of Anti-Platelet Drug-Induced Platelet Dysfunction
Annals of Laboratory Medicine
2019 .01
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Quinones ( Menadione , Benzoquinone , 및 2 , 3 - Dimethoxy - 1 , 4 - naphthoquinone ) 의 혈소판 세포독성 ( Effects of Various Quinones ( Menadione , Benzoquinone and 2 , 3-Dimethoxy-1 , 4-naphthoquinone ) on Rat Platelets )
한국독성학회지
1996 .06
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Effect of Hydroxybrazilin on Glutathione Depletion Induced by BrCCl3 and Menadione in Cultured Rat Hepatocytes
Environmental Analysis Health and Toxicology
1996 .10
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The Role of Rat Plasma in Manifesting Toxicity of Erythrocytes by Water-Soluble Menadione: Further Evidence of Free Radical Generation
대한약학회 학술대회
2000 .01
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Mean Platelet Volume and Mean Platelet Volume/Platelet Count Ratio in Chronic Urticaria
Annals of Dermatology
2019 .01
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Cisplatin 투여 후 백서의 간 및 신장에서 Glutathione 대사의 변화
영남의대학술지
1994 .01
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menadione 과 plasma 내의 protein thiol 의 비효소적인 화학반응에 의한 활성산소 생성 ( Generation of Reactive Oxygen Speies by Moenzymatic Reaction of Menadione With Protein Thiols in Plasma )
한국독성학회지
1997 .09
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Age Related Increase of Platelet Activation
대한의생명과학회지
2006 .12
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Differential Effects of Superoxide Radical on the Action Potentials in Ventricular Muscles, Purkinje Fibers and Atrial Muscles in the Heart of Different Aged Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
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