지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 281 - 287 (7page)
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초록· 키워드
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Impairment of hepatic metabolism of sulfur-containing amino acids has been known to be linked with induction of liver injury. We determined the early changes in the transsulfuration reactions in liver of rats challenged with a toxic dose of CCl₄ (2 m㏖/㎏, ip). Both hepatic methionine concentration and methionine adenosyltransferase activity were increased, but S-adenosylmethionine level did not change. Hepatic cysteine was increased significantly from 4 h after CCl₄ treatment. Glutathione (GSH) concentration in liver was elevated in 4~8 h and then returned to normal in accordance with the changes in glutamate cysteine ligase activity. Cysteine dioxygenase activity and hypotaurine concentration were also elevated from 4 h after the treatment. However, plasma GSH concentration was increased progressively, reaching a level at least several fold greater than normal in 24 h. γ-Glutamyltransferase activity in kidney or liver was not altered by CCl₄, suggesting that the increase in plasma GSH could not be attributed to a failure of GSH cycling. The results indicate that acute liver injury induced by CCl₄ is accompanied with extensive alterations in the metabolomics of sulfurcontaining amino acids and related substances. The major metabolites and products of the transsulfuration pathway, including methionine, cysteine, hypotaurine, and GSH, are all increased in liver and plasma. The physiological significance of the change in the metabolomics of sulfur-containing substances and its role in the induction of liver injury need to be explored in future studies.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (40)
참고문헌 신청
Adinolfi, L.E , 2005 , Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients , Hepatology 41 : 995 ~ 1003
Bagley, P.J , 1995 , Evaluation and modification of an assay procedure for cysteine dioxygenase activity: High-performance liquid chromatography method for measurement of cysteinesulfinate and demonstration of physiological relevance of cysteine dioxygenase activity in cysteine catabolism , Anal. Biochem 227 : 40 ~ 48
Corrales, F , 1992 , S-adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury , Hepatology 16 : 1022 ~ 1027
Corrales, F.J , 1999 , In vivo regulation by glutathione of methionine adenosyltransferase Snitrosylation in rat liver , J. Hepatol 31 : 887 ~ 894
Gaitonde,M.K , 1967 , A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids , Biochem. J 104 : 627 ~ 633
Bagley, P.J , 1995 , Evaluation and modification of an assay procedure for cysteine dioxygenase activity: High-performance liquid chromatography method for measurement of cysteinesulfinate and demonstration of physiological relevance of cysteine dioxygenase activity in cysteine catabolism , Anal. Biochem 227 : 40 ~ 48
Corrales, F , 1992 , S-adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury , Hepatology 16 : 1022 ~ 1027
Corrales, F.J , 1999 , In vivo regulation by glutathione of methionine adenosyltransferase Snitrosylation in rat liver , J. Hepatol 31 : 887 ~ 894
Gaitonde,M.K , 1967 , A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids , Biochem. J 104 : 627 ~ 633
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