지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 241 - 247 (7page)
이용수
초록· 키워드
오류제보하기
Korean ginseng (Panax ginseng C.A. Meyer) has been documented as a traditional treatment for diabetes, hyperglycemia and hyperlipidemia. The aim of this study was to investigate the antidiabetic effect of the cultured ginseng roots extracts (CGRs) in C57BL/KsJ db/db mice, a non-insulin-dependent diabetes mellitus animal model. CGRs were orally administered for a 10-week period and indices of diabetes including serum glucose, insulin, glycosylated hemoglobin (HbA1<SUB>C</SUB>), total cholesterol and triglycerides (TG) were measured. CGRs exhibited improving effects on diabetes indices in comparison with those of vehicle-treated mice; the plasma level of insulin was significantly increased, followed by improvement of glucose tolerance. The blood level of the HbA1<SUB>C</SUB> was also attenuated by CGRs treatment. In addition, the levels of total cholesterol and TG in CGRs-administered db/db mice were greatly reduced to the level of normal mice. Separately, the antidiabetic activities of the CGRs were correlated with the marked increase in the insulin-containing cells in islets from immunohistochemical analysis of pancreas. The results support that CGRs are beneficial for the improvement of type Ⅱ diabetes.
목차
재료 및 방법
결과
고찰
감사의 글
References
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Ali, M.B / 2006 / Methyl jasmonate and salicylic acid elicitation induces ginsenosides accumulation, enzymatic and non-enzymatic antioxidant in suspension culture Panax ginseng roots in bioreactors / Plant Cell Rep 25 : 613 ~ 620
2. [학술지(정기간행물)] - Basu, P / 2004 / Trading on transitional medicines / Nat. Biotechnol 22 : 263 ~ 265
3. [학술지(정기간행물)] - Defronzo, R.A / 2004 / Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes / Diabetes Rev 5 : 177 ~ 169
4. [학술지(정기간행물)] - Gibbons, G.F / 1992 / Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes / Biochem. J 287 (3) : 749 ~ 753
5. [학술지(정기간행물)] - Hirata, Y / 1994 / Mortality and causes of death in follow-up diabetic population in Japan / Diabetes Res. Clin. Pract 24 (suppl) : S295 ~ 298
2. [학술지(정기간행물)] - Basu, P / 2004 / Trading on transitional medicines / Nat. Biotechnol 22 : 263 ~ 265
3. [학술지(정기간행물)] - Defronzo, R.A / 2004 / Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes / Diabetes Rev 5 : 177 ~ 169
4. [학술지(정기간행물)] - Gibbons, G.F / 1992 / Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes / Biochem. J 287 (3) : 749 ~ 753
5. [학술지(정기간행물)] - Hirata, Y / 1994 / Mortality and causes of death in follow-up diabetic population in Japan / Diabetes Res. Clin. Pract 24 (suppl) : S295 ~ 298
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Antidiabetic Effects of Wild Ginseng Cultured Root Extract in db/db mice
한국실험동물학회 학술발표대회 논문집
2010 .08
-
Antidiabetic Effects of Wild Mountain Ginseng Cultured Root Extract in db/db mice
고려인삼학회 학술대회
2009 .05
-
Antidiabetic effects of Wild Ginseng extract in db/db mice
한국실험동물학회 학술발표대회 논문집
2007 .06
-
Antidiabetic and Antiobesity Effects of Wild Mountain Ginseng Cultured Root Extract in db/db Mice
한국실험동물학회 학술발표대회 논문집
2009 .08
-
Mulberry leaf extract displays antidiabetic activity in db/db mice via Akt and AMP-activated protein kinase phosphorylation
한국실험동물학회 학술발표대회 논문집
2018 .07
-
발효에 의한 오가피의 항당뇨 활성 촉진
동의생리병리학회지
2008 .01
-
Effects of germinated rough rice extract on type II diabetes mellitus in 3T3-L1 adipocytes and C57BLKS/J-db/db mice
한국실험동물학회 학술발표대회 논문집
2014 .08
-
Comparisons of antidiabetic activity between ethanol extract of white ginseng root and IH901 in streptozotocin-induced diabetic rats
대한약학회 학술대회
2002 .01
-
긴삼의 db/db 마우스에서 항당뇨 효과
약학회지
2006 .01
-
비인슐린 의존형 당뇨 환자에서 췌장의 크기:CT 계측
대한방사선의학회지
1997 .01
-
Wild Ginseng Prevents the Onset of High-Fat Diet Induced Hyperglycemia and Obesity in ICR Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
홍삼가수분해추출물의 db/db 마우스에서 신장 손상 예방효과
대한본초학회지(본초분과학회지)
2018 .01
-
Systemic immunity of obese-diabetes model (db/db) mice
Molecular & cellular toxicology
2010 .01
-
전사체 프로파일을 이용한 고려 홍삼의 항당뇨 기전 연구
약학회지
2008 .01
-
4종 한약 처방이 db/db 마우스의 혈당 개선에 미치는 영향
동의생리병리학회지
2004 .02
-
Antidiabetic Effects of Calcium Ion Water® in Neonatal Streptozotocin-Induced Noninsulin-Dependent Diabetes Mellitus in Rats
Laboratory Animal Research
2006 .03
-
The Insulin Level was Significantly Decreased in Transgenic Mice Co-overexpressing the Human Insulin Degrading Enzyme and Insulin-siRNA
Laboratory Animal Research
2006 .03
이 논문의 저자 정보
이 논문과 함께 이용한 논문
C57BL/KsJ-db/db 제2형 당뇨병 마우스에서 발아일품벼 추출물의 항당뇨효과
이연리
,
우관식
,
황인국
외 5명
한국식품영양과학회지
2012
.03
3T3-L1 Adipocyte와 C57BL/KsJ-db/db Mice에서 KOCAT-D1의 항당뇨 활성
양지희
,
원혜진
,
박호영
외 5명
한국식품영양과학회지
2010
.05
3,9-Diferuloyl-6-oxopterocarpen Inhibits Wrinkle by Antioxidant Effects for Oxidative Stress
Nam-Jin Lee
,
Hee-Youl Chai
,
Sun-Hee Pa
외 8명
Laboratory Animal Research
2008
.09
Genotoxicity Test on 3,9-Diferuloyl-6-oxopterocarpen, a New Agent Candidate for Anti-aging Material
Yu-Ri Jung
,
Sung-Min Pa
,
k
외 7명
Laboratory Animal Research
2008
.03
Anti-postmenopausal Effects of the Newly-Developed Phytoestrogen, FGF271, in vitro and in vivo
Nam-Jin Lee
,
Geun-Soo Kim
,
Bo-Yeon Kwak
외 6명
Laboratory Animal Research
2008
.03
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-014844082