지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 143 - 150 (8page)
이용수
초록· 키워드
오류제보하기
To perform the safety studies on 3,9-diferuloyl-6-oxopterocarpen (DFO), we accomplished the reverse mutation assay in Salmonella typhimurium and Escherichia coli, in vitro chromosomal aberration assay on Chinese hamster lung cell and in vivo bone marrow micronucleus test in male ICR mice. In the reverse mutation assay, this material treatment at the dose range up to 5,000 ㎍/plate did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA-with and without metabolic activation. In the in vitro chromosomal aberration assay, this material did not increase the number of cells having structural or numerical chromosome aberration. In the in vivo bone marrow micronucleus assay, no significant increase in the occurrence of micronucleated polychromatic erythrocytes was observed in male ICR mice administered this material. In conclusion, we suggested that DFO have no genotoxicity in reverse mutation assay, in vitro chromosomal aberration assay and in vivo bone marrow micronucleus test.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (11)
참고문헌 신청
1. [학술지(정기간행물)] - Ames, B.N / 1975 / Method for detecting carcinogens and mutagens with the Sallmonella/ mammalian-microsome mutagenicity test / Mutat. Res 31 : 347 ~ 364
2. [단행본] - Dean, B.J / 1984 / Assays for the Detection of Chemically-induced Chromosome Damage in Cultured Mammalian Cells in Mutagenicity Testing a Practical Approach / IRL Press Ltd. : 187 ~ 232
3. [기타자료] - Draize, J.H / 1959 / Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics / The Association of Food and Drug Officials of the United States, Bureau of Food and Drugs, Austin TX : 46 ~ 59
4. [학술지(정기간행물)] - Ishidate, M., Jr / 1981 / Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens / GANN Monograph Cancer Res 27 : 95 ~ 107
5. [학술지(정기간행물)] - Koyama, H / 1970 / A new cell line derived from newborn Chinese hamster lung tissue / GANN 61 : 161 ~ 167
2. [단행본] - Dean, B.J / 1984 / Assays for the Detection of Chemically-induced Chromosome Damage in Cultured Mammalian Cells in Mutagenicity Testing a Practical Approach / IRL Press Ltd. : 187 ~ 232
3. [기타자료] - Draize, J.H / 1959 / Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics / The Association of Food and Drug Officials of the United States, Bureau of Food and Drugs, Austin TX : 46 ~ 59
4. [학술지(정기간행물)] - Ishidate, M., Jr / 1981 / Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens / GANN Monograph Cancer Res 27 : 95 ~ 107
5. [학술지(정기간행물)] - Koyama, H / 1970 / A new cell line derived from newborn Chinese hamster lung tissue / GANN 61 : 161 ~ 167
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Genotoxicity Study of AS6, a Triterpenoid Derivatives
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2003 .01
-
CJ-11555의 유전독성에 관한 연구
Toxicological Research
2004 .06
-
CJ-11555의 유전독성에 관한 연구
Toxicological Research
2004 .03
-
Genotoxicity Studies on Carrageenan : Short-term In Vitro Assays
Toxicological Research
2009 .03
-
Genotoxicity Assessment of Erythritol by Using Short-term Assay
Toxicological Research
2013 .12
-
In Vitro Studies on the Genotoxic Effects of Wood Smoke Flavors
Toxicological Research
2008 .12
-
In Vitro Genotoxicity Assessment of a Novel Resveratrol Analogue, HS-1793
Toxicological Research
2014 .09
-
Erythropoietin(EPO)에 대한 변이원성시험
Toxicological Research
1999 .09
-
Acriflavine과 Guanosine 복합체(AG60)의 유전독성시험
한국환경성돌연변이·발암원학회지
2002 .06
-
유산균 발효 쌍화탕에 대한 단회 투여 경구 독성 및 유전 독성 연구
대한한의학회지
2011 .01
-
GST 추출물의 유전독성평가
동의생리병리학회지
2014 .12
-
Evaluation of Genotoxicity of Water and Ethanol Extracts from Rhus verniciflua Stokes (RVS)
Toxicological Research
2008 .06
-
새로운 플라보노이드 유도체인 DA-6034에 대한 유전독성에 관한 연구
Toxicological Research
2002 .12
-
Chrysin의 유전독성에 관한 연구
Toxicological Research
2005 .03
-
비 마약성 진통제 DA-5018의 변이원성 연구
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1996 .01
-
Lack of Mutagenicity Potential of Periploca sepium Bge. in Bacterial Reverse Mutation (Ames) Test, Chromosomal Aberration and Micronucleus Test in Mice
Environmental Analysis Health and Toxicology
2012 .01
-
Evaluation of the genetic toxicity of synthetic chemicals (Ⅴ) - in vitro Chromosomal Aberration Assay with 17 chemicals in Chinese Hamster Lung Cells -
한국환경성돌연변이·발암원학회지
2002 .12
-
형개연교탕(荊芥連翹湯) 추출물의 유전독성(遺傳毒性) 평가
대한본초학회지(본초분과학회지)
2007 .01
-
In vivo Micronucleus Assay - Historical Review and Current Improvement
한국환경성돌연변이·발암원학회지
2003 .09
이 논문의 저자 정보
이 논문과 함께 이용한 논문
3,9-Diferuloyl-6-oxopterocarpen Inhibits Wrinkle by Antioxidant Effects for Oxidative Stress
Nam-Jin Lee
,
Hee-Youl Chai
,
Sun-Hee Pa
외 8명
Laboratory Animal Research
2008
.09
Anti-postmenopausal Effects of the Newly-Developed Phytoestrogen, FGF271, in vitro and in vivo
Nam-Jin Lee
,
Geun-Soo Kim
,
Bo-Yeon Kwak
외 6명
Laboratory Animal Research
2008
.06
Antidiabetic Effect of Cultured Ginseng Root Extracts in Type 2 Diabetic Mice
Nam-Jin Lee
,
Yu-Ri Jung
,
Chun Mei Lin
외 2명
Laboratory Animal Research
2008
.06
Anti-menopausal Effect of the Newly-Developed Phytoestrogen, FGF271, in Vitro and in Vivo
Nam-Jin Lee
,
Geun-Soo Kim
,
Bo-Yeon Kwak
외 6명
Laboratory Animal Research
2008
.06
Therapeutic Effects of Lipoic Acid Complex on CCI₄-Induced Hepatic Fibrosis in Sprague-Dawley Rats
Nam-Jin Lee
,
Geun Soo Kim
,
Jong-Hun You
외 4명
Laboratory Animal Research
2007
.03
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-014753680