지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 293 - 299 (7page)
이용수
초록· 키워드
오류제보하기
Objectives：This study was conducted to evaluate the clinical efficacy and adverse effects of Oros-Methylphenidate(MPH) in children with attention deficit hyperactivity disorder.
Methods：A four week, open-label trial with forced flexible dosing strategy of Oros-methylphenidate was performed with 83 children with ADHD. For parental evaluation, parental version of SNAP-IV and visual analogue scale (VAS) were applied at baseline and endpoint. Every week CGS-S and adverse events chart were applied by the research clinicians. Baseline and endpoint body mass index(BMI) and blood pressure also compared.
Results：Significant improvement in VAS and SNAP-IV were demonstrated between baseline and week four. Significant improvement of CGI-S in every weeks after trial of Oros-MPH, especially in first two weeks. 78.3% of the participants experienced at least one adverse effects. Anorexia and insomnia were most common adverse effects, which lasted for about two weeks. Significant decrease in BMI and significant elevation of diastolic blood pressure were observed.
Conclusion：This study showed that Oros-MPH significantly reduced symptoms of ADHD in Korean children with ADHD, especially early period of medication trial. Meanwhile, many children also experienced adverse effects such as anorexia, insomnia. Moreover, increase in diastolic BP suggested that cautious evaluation of cardiac function should be needed.
Methods：A four week, open-label trial with forced flexible dosing strategy of Oros-methylphenidate was performed with 83 children with ADHD. For parental evaluation, parental version of SNAP-IV and visual analogue scale (VAS) were applied at baseline and endpoint. Every week CGS-S and adverse events chart were applied by the research clinicians. Baseline and endpoint body mass index(BMI) and blood pressure also compared.
Results：Significant improvement in VAS and SNAP-IV were demonstrated between baseline and week four. Significant improvement of CGI-S in every weeks after trial of Oros-MPH, especially in first two weeks. 78.3% of the participants experienced at least one adverse effects. Anorexia and insomnia were most common adverse effects, which lasted for about two weeks. Significant decrease in BMI and significant elevation of diastolic blood pressure were observed.
Conclusion：This study showed that Oros-MPH significantly reduced symptoms of ADHD in Korean children with ADHD, especially early period of medication trial. Meanwhile, many children also experienced adverse effects such as anorexia, insomnia. Moreover, increase in diastolic BP suggested that cautious evaluation of cardiac function should be needed.
목차
서론
대상 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Pliszka SR / 2003 / Psychiatric comorbidities in children with attention deficit hyperactivity disorder: implications for management 5 : 741 ~ 750
2. [학술지(정기간행물)] - Swanson J / 2003 / Development of a new once-a-day formulation of methylphenidate for the treatment of atenttion-deficit/hyperactivity disorder: proof-of-concept and proof-of-product studies 60 : 204 ~ 211
3. [학술지(정기간행물)] - Swanson J / 1999 / Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children 66 : 295 ~ 305
4. [학술지(정기간행물)] - Stele M / 2006 / A randomized, controlled effectiveness trial of OROS-methylphenidate compared to usual care with imediate-release methylphenidate in attention deficit- hyperactivity disorder 13 : 50 ~ 62
5. [학술지(정기간행물)] - Cox DJ / 2006 / Relative benefits of stimulant therapy with OROS methylphenidate versus mixed amphetamine salts extended release in improving the driving perfor-mance of adolescent drivers with attention-deficit/hyper-activity disorder 118 : 704 ~ 710
2. [학술지(정기간행물)] - Swanson J / 2003 / Development of a new once-a-day formulation of methylphenidate for the treatment of atenttion-deficit/hyperactivity disorder: proof-of-concept and proof-of-product studies 60 : 204 ~ 211
3. [학술지(정기간행물)] - Swanson J / 1999 / Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children 66 : 295 ~ 305
4. [학술지(정기간행물)] - Stele M / 2006 / A randomized, controlled effectiveness trial of OROS-methylphenidate compared to usual care with imediate-release methylphenidate in attention deficit- hyperactivity disorder 13 : 50 ~ 62
5. [학술지(정기간행물)] - Cox DJ / 2006 / Relative benefits of stimulant therapy with OROS methylphenidate versus mixed amphetamine salts extended release in improving the driving perfor-mance of adolescent drivers with attention-deficit/hyper-activity disorder 118 : 704 ~ 710
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