지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 82 - 87 (6page)
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초록· 키워드
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Objectives: The root barks of Periploca sepium Bge. (P. sepium) has been used in traditional Chinese medicine for healing wounds and treating rheumatoid arthritis. However, toxicity in high-doses was often diagnosed by the presence of many glycosides. The potential mutagenicity of P. sepium was investigated both in vitro and in vivo.
Methods: This was examined by the bacterial reverse mutation (Ames) test using Escherichia coli WP2uvrA and Salmonella typhimurium strains, such as TA98, TA100, TA1535, and TA1537. Chromosomal aberrations were investigated using Chinese hamster lung cells, and the micronucleus test using mice.
Results: P. sepium did not induce mutagenicity in the bacterial test or chromosomal aberrations in Chinese hamster lung cells, although metabolic activation and micronucleated polychromatic erythrocytes were seen in the mice bone marrow cells.
Conclusions: Considering these results, it is suggested that P. sepium does not have mutagenic potential under the conditions examined in each study.
Methods: This was examined by the bacterial reverse mutation (Ames) test using Escherichia coli WP2uvrA and Salmonella typhimurium strains, such as TA98, TA100, TA1535, and TA1537. Chromosomal aberrations were investigated using Chinese hamster lung cells, and the micronucleus test using mice.
Results: P. sepium did not induce mutagenicity in the bacterial test or chromosomal aberrations in Chinese hamster lung cells, although metabolic activation and micronucleated polychromatic erythrocytes were seen in the mice bone marrow cells.
Conclusions: Considering these results, it is suggested that P. sepium does not have mutagenic potential under the conditions examined in each study.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
CONFLICT OF INTEREST
REFERENCES
참고문헌 (27)
참고문헌 신청
Yook CS / 2001 / Periploca sepium bge / Gyeonwon Press :116
FuZhou Corona Science / Manufacture of hervals powders-plant powders extracts
Flixya Entertainment LLC / Chinese silkwine root-bark
Tumor Research Center / Antitumor and immunoregulatory effects of active components from cortex periplocae
Chu SS / 2012 / Insecticidal activity of the root bark essential oil of Periploca sepium Bunge and its main component / Nat Prod Res 26(10):926~932
FuZhou Corona Science / Manufacture of hervals powders-plant powders extracts
Flixya Entertainment LLC / Chinese silkwine root-bark
Tumor Research Center / Antitumor and immunoregulatory effects of active components from cortex periplocae
Chu SS / 2012 / Insecticidal activity of the root bark essential oil of Periploca sepium Bunge and its main component / Nat Prod Res 26(10):926~932
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UCI(KEPA) : I410-ECN-0101-2014-539-000804709