메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색
질문

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
The effects of rose petal extract (RPE) and Ganoderma lucidum culture (GLC) on the systemic and local anaphylactic reactions induced by compound 48/80 were investigated in mice. To induce systemic anaphylactic shock, male ICR mice were intraperitoneally challenged with a lethal dose (8 ㎎/㎏) of compound 48/80, a mast cell degranulator, 30 min after intraperitoneal administration of RPE or GLC (10, 32 or 100 ㎎/㎏). In comparison with 100% death, within 60 min, of control mice administered with vehicle, the mortalities of mice pretreated with 32 and 100 ㎎/㎏ of RPE were decreased to 20 and 0%, respectively. A dose-dependent decrease in the mortality was also achieved with GLC, resulting in 60, 20 and 0% in mice pretreated with 10, 32 and 100 ㎎/㎏, respectively. In local atopic dermatitis induced by intradermal injection of compound 48/80 (50 ㎍/site), the mice exhibited 169.1±10.5 times of scratching behaviors for 30 min and vascular leakage of Evan's blue; 118.3±16.9 mm2 in size and 2.61±0.48 μg in amount. The scratching behaviors induced by compound 48/80 was significantly attenuated by 6-day oral pretreatment with RPE (300 ㎎/㎏) to 86.9±16.4 times. In addition, Evan's blue leakage was also greatly reduced by RPE. In contrast, GLC did not decrease both the number of scratching behaviors and dye leakage, implying that different factors other than histamine are also involved in the atopic dermatitis induced by compound 48/80. Taken together, it is suggested that RPE contains ingredients inhibiting degranulation or action of inflammatory mediators from mast cells, and that could be a promising candidate for the prevention of systemic or local allergic reactions including atopic dermatitis.

목차

재료 및 방법
결과 및 고찰
감사의 글
참고문헌

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

이 논문과 함께 이용한 논문

최근 본 자료

전체보기

댓글(0)

0

UCI(KEPA) : I410-ECN-0101-2009-510-014753600