지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 137 - 143 (7page)
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초록· 키워드
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Allergic march is progression of allergic disorders from atopic dermatitis in infancy to asthma or allergic rhinitis later. Most prospective epidemiologic studies suggest that early atopic dermatitis is a risk factor for the development of asthma, whereas only some subtypes of early atopic dermatitis with concomitant wheeze or less prevalent sensitization were recently reported to be at increased risk of development of asthma during childhood. There is a question as to whether atopic dermatitis itself is a true risk factor for the development of asthma later or allergic march just reflects the order of appearance of atopic dermatitis and asthma or allergic rhinitis. Filaggrin gene mutations are associated with atopic dermatitis as well as asthma with atopic dermatitis in the Western countries, and skin barrier dysfunction can initiate systemic sensitization in the mouse model. Therefore, skin barrier dysfunction can explain partly the mechanism of allergic march. Thymic stromal lymphopoietin and interleukin-17 can also be involved in the development of asthma in the mouse model of allergic march. Moreover, microbial organisms on the skin can enhance or modulate the immunologic mechanism of allergic march. A few pharmacologic agents have been investigated to interrupt allergic march, and the results are not promising. To find effective interruption of allergic march, a well-defined target, further understanding of the mechanism, and development of novel agents or combination of previous agents to modulate immune response remain to be solved.
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참고문헌 (24)
참고문헌 신청
[학술지
Almqvist C / 2007 / Early predictors for developing allergic disease and asthma: examining separate steps in the 'allergic march' / Clin Exp Allergy 37 : 1296 ~ 1302
Arshad SH / 2005 / Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age / Chest 127 : 502 ~ 508
Burgess JA / 2008 / Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle age / J Allergy Clin Immunol 122 : 280 ~ 285
Cork MJ / 2006 / New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions / J Allergy Clin Immunol 118 : 3 ~ 21
Almqvist C / 2007 / Early predictors for developing allergic disease and asthma: examining separate steps in the 'allergic march' / Clin Exp Allergy 37 : 1296 ~ 1302
Arshad SH / 2005 / Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age / Chest 127 : 502 ~ 508
Burgess JA / 2008 / Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle age / J Allergy Clin Immunol 122 : 280 ~ 285
Cork MJ / 2006 / New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions / J Allergy Clin Immunol 118 : 3 ~ 21
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