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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.6
- 수록면
- 158 - 163 (6page)
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This study was performed to investigate the anti-obesity effect of Hwalgidan SJ-201 in high-fat diet-fed Zucker Fa/- rats. Obesity was induced by feeding on high-fat diet containing 3% corn oil and 1% cholesterol for 8 weeks, in which Hwalgidan SJ-201 (3%) was added to the diet for the treatment group. The rats fed on the high-fat diet showed increased gain of body weights, leading to enhanced feed efficiency ratio. In addition, cholesterol, low-density lipoproteins (LDL), alanine transaminase, aspartate transaminase, total proteins and creatinine were increased, in comparison with decrease in high-density lipoproteins (HDL), in male rats. In females, cholesterol, LDL, triglycerides, lactate dehydrogenase and creatinine were enhanced, in contrast to lowered level of HDL. Moreover, high-fat diet induced hepatic lipid peroxidation, resulting in increased relative liver weights. Such changes in body weights as well as parameters indicating obesity and hepatic injury were attenuated by feeding on Hwalgidan SJ-201, although there were some fluctuation of biomarkers and gender differences in the response to the diet and Hwalgidan SJ-201. Taken together, it is suggested that Hwalgidan SJ-201 has potential for improving high-fat diet-induced obesity and ensuing hepatic burden by regulating lipid profiles and radical reactions.
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