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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.21 No.3
발행연도
2005.9
수록면
241 - 248 (8page)

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Obesity is a serious risk factor for so-called lifestyle-related diseases such as diabetes, cardiovascular disease and hypertension. Although obesity is caused by various environmental and genetic factors, the consumption of high-fat diet (HFD) is thought to be one of the main factors. This study was designed to evaluate two rat models, Zucker model and HFD-fed Sprague-Dawley (SD) model, for studying obesity. The order of epididymal fat pad weights were as follows: Zucker obese rats (0.025±0.003) ＞ HFD-fed SD rats (0.016±0.004) ＞ Normal diet (ND)-fed SD rats (0.012±0.001) ＞ Zucker lean rats (0.011±0.000). Zucker obese group and HFD-fed SD group showed increasing tendency in blood glucose concentrations. On the other hand, serum triglyceride levels, free fatty acid (FFA) levels and cholesterol levels were significantly higher in only Zucker obese rats compared with other groups. The histological examination of the liver tissue from Zucker obese rats revealed an altered liver structure with a huge macrovacuolar steatosis disseminated from the portal space to the centrolobular vein. In HFD-fed SD rats, enlarged hepatocytes with microvacuoles were irregularly disseminated. There was also significant increment in serum aspartate transaminase (AST) levels in HFD-fed SD rats, associated with accumulation of lipid in liver. While mineralization of renal tubule and enlargement of pancreatic islet were prominent features of Zucker obese rats, these changes were not seen in HFD-fed SD rats and in Zucker lean rats. Subcutaneous triglyceride levels of Zucker obese rats were statistically higher than those of other groups. These results supported that Zucker obese rat is a useful model of obesity research, as reported previously. On the other hand, triglyceride levels in subcutaneous adipose tissue of HFD-fed SD rats were not significantly different from those of other groups. These results suggested that HFD-fed SD rat model is not suited for investigation of lipolytic effect in subcutaneous adipose tissue. However, HFD-fed SD rats were induced slight obesity compared with Zucker obese rats. Although there were no significant effects from several analytic factors, HFD-fed SD rat model may be a useful tool for studying the mechanisms by which dietary fat influences the regulation of energy balance. Recently, numerous studies on obesity using rodents feeding of a various type of HFD have been preceded. Hence, further studies, considering various feeding duration, different diet (ND and HFD) types and fat content, may be necessary to establish useful animal model for HFD-induced obesity and diabetes.
#High fat diet #SD rat #Zucker rat #obesity

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