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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국실험동물학회 Laboratory Animal Research THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE Vol.20 No.1
- 발행연도
- 2004.3
- 수록면
- 81 - 88 (8page)
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초록· 키워드
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The objective of this study was to determine genotoxic potential of Geranti Bio-Ge Yeast<SUP>ⓡ</SUP>, an organic germanium naturally synthesized in yeasts. For the in vitro reverse mutation test, we set the treatment levels of Geranti Bio-Ge Yeast<SUP>ⓡ</SUP> at 312.5, 625, 1,250, 2,500 and 5,000 ㎍/plate using Salmonella typhimurium strains (TA1535, TA1537, TA98 and TA100) and Escherichia coli WP2uvrA (pKM101). No significant mutagenic activity was observed both in the presence and absence of S9 mix with all Salmonella and Escherichia strains used. For the in vitro chromosomal aberration test using Chinese hamster lung fibroblasts, we set the treatment levels of Geranti Bio-Ge Yeast<SUP>®</SUP> at 1,250, 2,500 and 5,000 ㎍/㎖, No significant increase in the structural and numerical chromosome aberration was observed in both the presence and absence of S9 mix. In the micronucleus test, mice were orally administered with 125, 250, 500, 1,000, 2,000 or 5,000 ㎎/㎏ of Geranti Bio-Ge Yeast<SUP>®</SUP>, or intraperitoneally with mitomycin C as a positive control. The mice were sacrificed 24 hours later, and bone marrow was collected and stained with Giemsa solution. There was no evidence that Geranti Bio-Ge Yeast<SUP>®</SUP> significantly induced micronucleated polychromatic erythrocytes. In conclusion, it is suggested that Geranti Bio-Ge Yeast<SUP>®</SUP> do not have a genotoxic potential under the conditions of this study.
목차
Introduction
Materials and Methods
Results
Discussion
References
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