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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 231 - 238 (8page)
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Selenoprotein M (SeIM) is a eukaryotic selenoprotein containing one selenocysteine (Sec) and Sec insertion sequence (SECIS) in 3' untranslated regions. In order to examine whether SelM expression and selenium treatment were influenced on expression level of the apoptosis-related proteins, pCMV/hlDE fusion gene were overexpressed in the HEK 293 cell line and hSelM-Tg rat. Herein, it is concluded that; ⅰ) two transgenic mice were identified by PCR analysis using specific primers by screening 28 newborn founder mice, ⅱ) the GFP-hSeIM fusion protein were successfully detected on the protein level in the HEK 293 cell line and hSeIM-Tg rat. ⅲ) it was also observed that p53 proteins were significantly changed in the HEK 293 cell under the condition of hSeIM overexpression and selenuim treatment, while not changed in the kidney tissue of hSeIM-Tg rat. ⅳ) Bax proteins were significantly changed in the kidney of hSeIM-Tg rat under the condition of hSeIM overexpression and sel treatment, while not changed in the HEK 293 cell line. ⅴ) Bel2 proteins in the HEK 293 cell were significantly decreased in the hSeIM transfectants, but hSeIM-Tg rat were shown the different expression patterns in the sel treated condition. These results suggest that selenium treatment and SeIM overexpression were differently influenced the expressions of apoptosis-related proteins in the tumor cell line and transgenic tissue
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고찰
감사의 글
참고문헌
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Birringer, M / 2002 / Trends in selenium biochemistry 19 : 693 ~ 718
2. [학술지(정기간행물)] - Bruk, R.F / 1999 / Orphan selenoproteins 21 : 231 ~ 237
3. [학술지(정기간행물)] - Ranger, A.M / 2001 / Mouse models of cell death 28 : 113 ~ 118
4. [학술지(정기간행물)] - Carlson, B.A / 2004 / Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essetial role of selenoproteins in liver function 279 : 8011 ~ 8017
5. [학술지(정기간행물)] - Clark, L.C / 1996 / Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group 276 : 1957 ~ 1963
2. [학술지(정기간행물)] - Bruk, R.F / 1999 / Orphan selenoproteins 21 : 231 ~ 237
3. [학술지(정기간행물)] - Ranger, A.M / 2001 / Mouse models of cell death 28 : 113 ~ 118
4. [학술지(정기간행물)] - Carlson, B.A / 2004 / Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essetial role of selenoproteins in liver function 279 : 8011 ~ 8017
5. [학술지(정기간행물)] - Clark, L.C / 1996 / Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group 276 : 1957 ~ 1963
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UCI(KEPA) : I410-ECN-0101-2009-510-016364165