메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색
질문

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
Turnip extract is known to have anti-fibrogenic effect traditionally but there is little study regarding the effective components of turnip extracts and their mechanism. The aim of this study is to search the effective components of turnip extracts using rat hepatic stellate cell lines and animal models. The anti-fibrogenic effects of the six components out of hexane and water fraction of turnip extract were examined. Changes of cell proliferation, expression of genes and proteins related to liver cirrhosis, and induction of cell apoptosis were analyzed. The six components were confirmed to significantly decrease cell proliferation, and induction of cell apoptosis were slightly changed. Especially, turnip/Hx/Hx fraction and turnip/water/EtOH precipitate among these components were confirmed to have anti-fibrogenic effects. On the basis of these results, turnip/Hx/Hx fraction was primarily fractionated with TLC (Thin Layer Chromatography), while the anti-fibrogenic effect of turnip/water/EtOH precipitation extract was examined through an animal model for liver fibrosis. In the laboratory animal study, significant anti-fibrogenic effect was confirmed with histological and serological methods in the experimental group with turnip/water/EtOH precipitation extract mixed diet. The seven fractions out of turnip/Hx/Hx component through TLC were investigated for cell apoptosis induction, and among them four fractions were confirmed to have possible anti-fibrogenic effects. Among these four, 5/AT extract was secondarily fractionated with TLC to six fractions; turnip/Hx/5-1 to turnip/Hx/5-6, and these were investigated for cell apoptosis induction. As a result, two of them were confirmed to possibly induce cell apoptosis as tetrandrine does. In conclusion, the present study identified the anti-fibrogenic component among the turnip extract, and suggests that it could be a potential component in preventive and therapeutic agent for liver cirrhosis.

목차

재료 및 방법
결과 및 고찰
참고문헌

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

이 논문과 함께 이용한 논문

최근 본 자료

전체보기

댓글(0)

0

UCI(KEPA) : I410-ECN-0101-2009-510-016363153