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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 113 - 121 (9page)
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초록· 키워드
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Objectives
In human myeloid leukemia cells, there are no specific features of apoptosis compared with apoptosis in other cell types. Solanum nigrum L.(SNL) is a deciduous tree, which is widely distributed in Korea with reported anti-tumor, anti-inflammatory and non-specific immune-enhancing properties. Although the plant has been clinically used for treating a variety of diseases, its bioactive ingredients are unknown and its mode of action potential has never been investigated. Thus anti-tumor property of methanol extract was investigated.
Methods
In this study, anti-tumor property of methanol extract was investigated by determining its in vitro growth-inhibitory effects on human myeloid leukemia cells. XTT proliferation assay, DNA fragmentation, immunoblot analysis, densitometric analysis were used.
Results
1.The methanol fraction of the extracts of SNL induced mitochondria-mediated apoptosis in human myeloid leukemia cells.
2. The methanol fraction exhibited relatively higher cytotoxic activity in a dose-dependent manner than chloroform, and hexane fraction.
3. Typical ladder profile of Oligonucleosomal fragments were appeared.
4. The secreted cytosolic cytochrome C level was increased by treatment of methanol fraction.
Conclusions
Methanol fraction of SNL is capable of inducing apoptosis in human myeloid leukemia cells.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
.Zamzami N / 2001 / The mitochondrion in apoptosis:how Pandora’s box open / Nature Rev 2 (1) : 67 ~ 71
Antonsson B / 2004 / Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways / Mol. Cell. Biochem 256 (1) : 141 ~ 155
Bennett JM / 1985 / Proposed revised criteria for the classification of acute myeloid leukemia / Ann Intern Med 103 (4) : 626 ~
Chan SL / 2004 / Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities / Clin Exp Pharmacol Physiol 31 (3) : 119 ~ 128
Cheung JY / 2005 / Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells / Cancer Lett 217 (2) : 203 ~ 211
Antonsson B / 2004 / Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways / Mol. Cell. Biochem 256 (1) : 141 ~ 155
Bennett JM / 1985 / Proposed revised criteria for the classification of acute myeloid leukemia / Ann Intern Med 103 (4) : 626 ~
Chan SL / 2004 / Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities / Clin Exp Pharmacol Physiol 31 (3) : 119 ~ 128
Cheung JY / 2005 / Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells / Cancer Lett 217 (2) : 203 ~ 211
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