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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
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대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제13권 제3호
발행연도
2007.9
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213 - 221 (9page)

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This study was designed to investigate the correlation between the expression rate of p53 and p21 proteins, c-erbB-2 oncoprotein and TGF-β1 and tumor prognostic factors in colon cancer including the tumor size, histological differentiation and Dukes' stage. The expression rate of p53 protein was 11.4% (4 cases) at well differentiation, 48.6% (17 cases) at moderately differentiation, and 17.1% (6 cases) at poorly differentiation. In other words, the poorer differentiation, the higher the expression rate of p53 protein (P＜0.05). The expression rate of p21 protein was 17.1% (6 cases) at well differentiation, 40.0% (14 cases) at moderately differentiation, and 8.6% (3 cases) at poorly differentiation, indicating that, as the histological malignant degeneration progressed, the expression rate of p21 protein decreased distinctively (P＜0.05). However, the correlation of the above mentioned proteins with tumor size and Dukes' stage was not recognized. The expression rate of c-cerbB-2 oncoprotein was 11.4% (4 cases) at well differentiation, 54.3% (19 cases) at moderately differentiation, and 17.1% (6 cases) at poorly differentiation, indicating that the poorer differentiation, the higher expression rate of c-erbB-2 oncoprotein (P＜0.05). The expression rate of TGF-β1 was 17.1% (6 cases) at well differentiation, 48.6% (17 cases) at moderately differentiation, and 11.4% (4 cases) at poorly differentiation. As Dukes' stage progressed, the expression rate of TGF-β1 was 8.6% (3 cases) in stage A, 20.0% (7 cases) in stage B, 37.1% (13 cases) in stage C, and 11.4% (4 cases) in stage D. There was a difference in expression rates between Dukes' stages (P＜0.05). In 10 cases, p53 protein was positive while p21 protein was negative, and in 6 cases, p53 protein was negative whereas p21 was positive (P＜0.05). Therefore, a statistically significant inverse correlation between the expression rate of p53 protein and that of p21 protein was observed. In conclusion, since there was a signigicant correlation between histological differentiation of colon cancer and the expressions of p53 and p21 proteins and c-erbB-2 oncoprotein, and between Dukes' stage and the expression of TGF-β1, it was confirmed that the overexpression of p53 and p21 proteins, c-erbB-2 oncoprotein, and TGF-β1 is closely associated with the occurrence of colon cancer and its progress. Accordingly, this study may be greatly beneficial to the presumption of diagnosis, treatment and prognosis of colon cancer patients.
#Prognostic factors #p53 protein #p21 protein #c-erbB-2 oncoprotein #TGF-β1 #Histological differentiation #Dukes' stage

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REFERENCES

참고문헌 (31)

참고문헌 신청
1. [학술지(정기간행물)] - Akagi, M / 1996 / Inhibition of cell growth by transforming growth facctor 1 in associated with p53-independent induction of p21 in gastric carcinoma cells / J Cancer Res. 87 : 377 ~ 384 google schola 2. [학술지(정기간행물)] - Barger, MS / 1988 / Correlation of c-erbB-2 gene amplication and protein expression in human breast carcinoma with nodal status and nuclear grading / Cancer Res. 48 : 1238 ~ 1240 google schola 3. [학술지(정기간행물)] - Digiuseppe, JA / 1995 / p53-independent expression of the cyclin dependent kinase in pancreatic carcinoma / Am J Pathol. 147 : 884 ~ 888 google schola 4. [학술지(정기간행물)] - Elkablawy, MA / 2001 / Apoptosis and cell cycle regulatory proteins in colorectal carcinoma: relationship to tumor stage and patient survival / J Pathol. 194 : 436 ~ 443 google schola 5. [학술지(정기간행물)] - Ferrandina, G / 2000 / p21WAF/CIP1 protein expression in primary ovarian cancer / Int Oncol. 17 : 1231 ~ 1235 google schola

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UCI(KEPA) : I410-ECN-0101-2009-510-015971320