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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 514 - 520 (7page)
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초록· 키워드
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Purpose: Hepatocellular carcinomas (HCC) are one of
the most common cancers in Korea. The mechanism of
HCC development is still unclear, and the aberration of
the tumor suppressor genes in HCC remains to be
clarified.
Materials and Methods: To study the expressions of
p53 and Rb protein, and their correlation with the clinicopathological
parameters in HCC, 68 patients, with surgically
resected hepatocellular carcinomas, were analyzed
by an immunohistochemical method. The expressions
of p53 and Rb protein were classified into three
categorizes, depending on the percentage of stained
cells.
Results: The expression of the p53 protein was 51.5%
(35/68), and was significantly correlated with differentiation
(p<0.05). The altered Rb protein expression was
72.2% (49/68). The expressions of p53 and altered Rb
protein had no significant correlation with the tumor size,
gender, WHO histological pattern, cirrhosis or vascular
invasion (p<0.05). There was a positive correlation between
p53 and Rb protein overexpression (p<0.05). The
expressions of p53 and Rb protein had correlation with
the Ki-67 labeling index (p<0.05).
Conclusion: These findings suggest the aberrant expressions
of p53 and Rb protein may play a role in the
progression and carcinogenesis of HCC. (Cancer Res Treat. 2003;35:514-520)
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