지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 74 - 78 (5page)
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초록· 키워드
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Multi-drug resistance (MDR) is a major problem in cancer chemotherapy and has often ended up with termination of the therapy. The aim of this study was to identify any fractions of Korean red ginseng that would be effective in modulating for MDR. Although ginsenosides have been reviewed as possible MDR modulators, the MDR modulation activity of the other component is unknown. Therefore, a red ginseng was extracted with methanol, ether, ethylacetate, and n-butanol, followed by several fractionations by silica gel chromatography. And the activity of MDR modulating for these fractions was examined via sulforrhodamine B assay. We have found that several ether fractions, as nonsaponin components are effective on MDR modulation. We have expect that these results helpful to improvement of cancer chemotherapy.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULT AND DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - / 1991 / Clinical implications of multidrug resistance to chemotherapy
2. [학술지(정기간행물)] - / 1989 / The biochemistry of p-glycoprotein-mediated multidrug Resistance. Annu. Rev. Biochem. 58 : 137 ~ 171
3. [학술지(정기간행물)] - / 1990 / Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev. 42 : 155 ~ 199
4. [학술지(정기간행물)] - / 1993 / Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann. Rev. Biochem. 62 : 385 ~ 427
5. [학술지(정기간행물)] - / i. / The multidrug transporter 263 12163-12166 (1988)
2. [학술지(정기간행물)] - / 1989 / The biochemistry of p-glycoprotein-mediated multidrug Resistance. Annu. Rev. Biochem. 58 : 137 ~ 171
3. [학술지(정기간행물)] - / 1990 / Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev. 42 : 155 ~ 199
4. [학술지(정기간행물)] - / 1993 / Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann. Rev. Biochem. 62 : 385 ~ 427
5. [학술지(정기간행물)] - / i. / The multidrug transporter 263 12163-12166 (1988)
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UCI(KEPA) : I410-ECN-0101-2009-524-016756878