지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 375 - 385 (11page)
이용수
초록· 키워드
오류제보하기
Conventional cancer chemotherapy is seriously limited by tumor cells exhibiting multidrug resistance (MDR), which is caused by changes in the levels or activity of membrane transporters that mediate energy-dependent drug efflux and of proteins that affect drug metabolism and/or drug action. Cancer scientists and oncologists have worked together for some time to understand anticancer drug resistance and develop pharmacological strategies to overcome such resistance. Much focus has been on the reversal of the MDR phenotype by inhibition of ATP-binding cassette (ABC) drug transporters. ABC transporters are a family of transporter proteins that mediate drug resistance and low drug bioavailability by pumping various drugs out of cells at the expense of ATP hydrolysis. Many inhibitors of MDR transporters have been identified, and though some are currently undergoing clinical trials, none are in clinical use. Herein, we briefly review the status of MDR in human cancer, explore the pathways of MDR in chemotherapy, and outline recent advances in the design and development of MDR modulators.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
-
Knockdown of MDR1 Increases the Sensitivity to Adriamycin in Drug Resistant Gastric Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
위암세포에서 다약물 내성기전으로서 ATP-Binding Cassette (ABC) Transporters의 발현과 기능
Annals of Surgical Treatment and Research
2005 .05
-
Effects of Non-Saponin Red Ginseng Components on Multi-drug Resistance
Journal of Ginseng Research
2007 .06
-
Benzotriazepin 유도체의 암세포에 대한 다약제내성 억제효과
약학회지
2005 .01
-
Platinum Transporters and Drug Resistance
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
다제내성결핵 환자에서 표준 1차 항결핵제 치료 중 발생한 획득 내성
Tuberculosis and Respiratory Diseases
2009 .01
-
MULTIDRUG RESISTANCE IN CANCER
대한외과학회 학술대회 초록집
1998 .11
-
Effects of Ginseng Saponin on Modulation of Multidrug Resistance
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Genetic Polymorphisms in Drug Transporters and Regulatory Xenobiotic Receptors in Korean Population
한국환경성돌연변이·발암원학회지
2003 .12
-
초회내성으로 진단된 다제내성 폐결핵 환자들의 임상적 특징
Tuberculosis and Respiratory Diseases
2001 .01
-
The Association of Increased Lung Resistance Protein Expression with Acquired Etoposide Resistance in Human H460 Lung Cancer Cell Lines
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
다제 내성 암세포에서의 Polyamine 특성
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1997 .01
-
Toxicological Relevance of Transporters
Toxicological Research
2007 .03
-
Medical Treatment of Pulmonary Multidrug-Resistant Tuberculosis
Infection and Chemotherapy
2013 .01
-
분자핵의학 기법을 이용한 다약제내성 진단
대한핵의학회지
2004 .01
-
Characterization and Resistance Mechanisms of A 5-fluorouracil-resistant Hepatocellular Carcinoma Cell Line
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
다제내성결핵의 진단과 치료
대한내과학회지
2015 .01
-
Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C＞T Gene Polymorphism in Differentiated Thyroid Cancers
Asian Pacific journal of cancer prevention : APJCP
2013 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0