지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.12 No.1
- 발행연도
- 2007.3
- 수록면
- 29 - 34 (6page)
이용수
초록· 키워드
오류제보하기
The production of mevinolin, a potent hypocholesterolemic drug, and the bioconversion of isoflavones were investigated in soybeans fermented with Monascus pilosus KFRI-1140. The highest yields of 2.94 mg mevinolins and 1.13 mg isoflavone aglycones per g dry weight of soybean were obtained after 20 days of fermentation. Mevinolin was present in the fermentation substrate predominantly in the hydroxycarboxylate form (open lactone, 94.8～96.7%), which is currently being used as an hypocholesterolemic agent. The significant (p＜0.01) bioconversion (96.6%) of the glucoside isoflavones (daidzin, glycitin, genistin) present in the soybean to the bioactive aglycones (daidzein, glycitein, genistein), with a 15.8-fold increase of aglycones was observed. The results suggest that Monascus-fermented soybean has potential as a novel medicinal food or multifunctional food supplement.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (29)
참고문헌 신청
Buckland B, Gbewonyo K, Hallada T, Kaplan L, Masurekar P. 1989. Novel microbial products for medicine and agriculture. Elsevier, Amsterdam. p 161-169.
Juzlova P, Martinkova L, Kren V. 1996. Secondary metabolites of the fungus Monascus: a review. J Indus Microbiol 16: 163-170.
Goldstein JL, Brown MS. 1984. Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol. J Lipid Res 25: 1450-1461.
Manzoni M, Rollini M. 2002. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl Microbiol Biotechnol 58: 555-564.
Friedrich J, Zuzek M, Bencina M, Cimerman A, Strancar A, Radez I. 1995. High performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths. J Chromatogr A 704: 363-367.
Juzlova P, Martinkova L, Kren V. 1996. Secondary metabolites of the fungus Monascus: a review. J Indus Microbiol 16: 163-170.
Goldstein JL, Brown MS. 1984. Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol. J Lipid Res 25: 1450-1461.
Manzoni M, Rollini M. 2002. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl Microbiol Biotechnol 58: 555-564.
Friedrich J, Zuzek M, Bencina M, Cimerman A, Strancar A, Radez I. 1995. High performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths. J Chromatogr A 704: 363-367.
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UCI(KEPA) : I410-ECN-0101-2009-511-016553532