지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 145 - 151 (7page)
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초록· 키워드
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Leukotactin-1(Lkn-1) / CCL15 has been known as a potent chemoattractant of leukocytes. However, the precise function of Lkn-1 in human neutrophils has not been explained well. In the present study, we investigated the contribution of Lkn-1 in chemotactic activity of human neutrophils. Both CCR1 and CCR3 mRNA expressions are strongly expressed in human neutrophils but CCR2 protein expression was uniquely detected on the cell surface. Lkn-1 binding to CCR1 and CCR3 induced chemotactic activity of neutrophils. Chemotactic index of Lkn-1 was comparable to that of IL-8. MIP-1α / CCL3 binding to CCR1 and CCR5 has no effect on neutrophil migration. Cell migration, in response to Lkn-1, was blocked by pertussis toxin (Ptx), a G<SUB>o</SUB>G<SUB>i</SUB> protein inhibitor, and U73122, a phospholipase C (PLC) inhibitor but not by protein kinase C inhibitor such as rottlerin, and Ro-31-8425. Taken together, our results demonstrate that Lkn-1 transduces the chemotaxis signal through G<SUB>o</SUB>G<SUB>i</SUB> protein and PLC. This finding provides the molecular mechanism by which Lkn-1 may contribute to neutrophil movement into the site of inflammation.
목차
영어초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-510-017357222