지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Asthma is an inflammatory airway disease and is characterized by the releases of inflammatory mediators including chemokines. They are mainly associated with the recruitment, activation and dysregulation of specific inflammatory cells, especially neutrophils in neutrophilic asthma. CC chemokines bind to CC chemokine receptors (CCRs) in the surface of their target cells. The aims of this study are to examine the CCR expression in neutrophils of bronchoalveolar lavage fluid (BALF) of asthmatic patients and to determine the alternation of migration and apoptosis of neutrophils by the BALF. We demonstrate that CCR3 strongly expresses in BALF neutrophils of asthmatic patients as compared to other CCRs and increases during apoptosis of the BALF neutrophils. The migration of asthmatic blood neutrophils increases in response to asthmatic BALF as compared to BALF of normal volunteer. In addition, asthmatic BALF includes the higher levels of IL-8 protein than normal BALF and it has no effect on apoptosis of asthmatic blood neutrophils. Taken together, our results indicate that CCR3 expression may be associated with unknown function of asthmatic BALF neutrophils and BALF may be involved in the recruitment of neutrophils into the airway, but not in the neutrophils apoptosis.
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참고문헌 (19)
참고문헌 신청
Bonecchi R / 1999 / Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-γ in human neutrophils / J Immunol 162:474~479
Braman SS / 2006 / The global burden of asthma / Chest 130:4~12
Busse WW / 2003 / Mechanisms of asthma / J Allergy Clin Immunol 111:799~804
Cheng SS / 2001 / Granulocyte macrophage colony stimulating factor up-regulates CCR1 in human neutrophils / J Immunol 166:1178~1184
Culpitt SV / 2002 / Effect of theophylline on induced sputum inflammatory indices and neutrophilc in chronic obstructive pulmonary disease / Am J Respir Crit Care Med 165:1371~1376
Braman SS / 2006 / The global burden of asthma / Chest 130:4~12
Busse WW / 2003 / Mechanisms of asthma / J Allergy Clin Immunol 111:799~804
Cheng SS / 2001 / Granulocyte macrophage colony stimulating factor up-regulates CCR1 in human neutrophils / J Immunol 166:1178~1184
Culpitt SV / 2002 / Effect of theophylline on induced sputum inflammatory indices and neutrophilc in chronic obstructive pulmonary disease / Am J Respir Crit Care Med 165:1371~1376
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UCI(KEPA) : I410-ECN-0101-2012-510-004465561