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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Ankyrins are a ubiquitously expressed family of intracellular adaptor proteins involved in targeting diverse proteins to specialized membrane domains in both the plasma membrane and the endoplasmic reticulum. Canonical ankyrins are 190~220 kDa proteins expressed in most tissues and cell types and comprise a membrane-binding domain (MBD) of 24 ANK repeats, a spectrin-binding domain, a death domain and a C-terminal domain. Rescue studies with ankyrin-B/G chimeras have identified the C-terminal domain of ankyrin-B as the defining domain in specifying ankyrin-B activity. but the function of C-terminal domain of ankyrin-B is, however, not known. We report here that the C-terminal domain of ankyrin-B is capable of interacting with the C-terminal Region of Hsp40. The Hsps are induced not only by heat shock but also by various other environmental stresses. Hsps are also expressed constitutively at normal growth temperatures and have basic and indispensable functions in the life cycle of proteins as molecular chaperones, as well as playing a role in protecting cells from the deleterious stresses. The binding sites required in the interaction between C-terminal domain of ankyrin-B and C-terminal region of Hsp40 were characterized using the yeast two-hybrid system and GST-pull down assay. The interaction between ankyrin-B and Hsp40 represents the first direct evidence of ankyrin's role as chaperones.
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영어 초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Identification of Proteins Interacting with C-Terminal Region of Human Ankyrin-G
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C-Terminal Region of Ankyrin-B Interact with Z-Line Portion of Titin
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열충격단백질 70에 대한 연구
대한물리치료학회지(JKPT)
2000 .01
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Cerebellar Heat Shock Protein 25 is not Changed by Hyperthermic Induction
Laboratory Animal Research
2007 .12
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Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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열충격 단백질의 신경정신의학적 의의와 중요성
생물정신의학
2007 .01
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후두 편평 세포암에서의 HSP27 발현에 관한 연구
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2001 .01
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아밀로이드 베타에 의한 신경세포 사멸과 이에 대한 열충격 단백질 90의 세포 보호효과
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2008 .03
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The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis
Yonsei Medical Journal
2015 .01
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급성 뇌경색 환자에서 혈중 Human Heat Shock 단백질 농도 및 항체수준의 상관관계
대한뇌졸중학회지
2005 .01
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Antibodies to Heat Shock Protein 70kDa and 90kDa in the Patients with Schizophrenia, and Their Relationship with Clinical Variables
생물정신의학
1999 .01
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Heat Shock Protein 90β Inhibits Phospholipase Cγ-1 Activity in vitro
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2006 .12
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Heat Shock Protein 90 (HSP90) and Immune Regulation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .03
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신세포암종에서 Heat Shock Protein 27의 발현과 세포자멸사에 대한 연구
Journal of Pathology and Translational Medicine
2006 .01
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Evidence of Multimeric Forms of HSP70 with Phosphorylation on Serine and Tyrosine Residues - Implications for Roles of HSP70 in Detection of GI Cancers
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma
Journal of Pathology and Translational Medicine
2013 .01
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Transcriptional responses of heat shock protein 90 (HSP90) and heat shock protein 83 (HSP83) genes by salinity changes in the intertidal crab Macrophthalmus japonicus
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2019 .10
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내독소로 전처치한 쥐 폐포상피에서 HSP70 유도가 추가 내독소 자극에 따른 IL-6 생성능 및 세포생존도에 미치는 영향
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2005 .01
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UCI(KEPA) : I410-ECN-0101-2009-510-017341035