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- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 75 - 85 (11page)
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This study was designed to evaluate the possible DNA damaging effects of T-2 toxin using an alkaline single cell gel electrophoresis (SCGE) comet assay and also to investigate toxic effects in chickens. A total of 20 chickens were used in these experiments. Graded concentrations of dietary T-2 toxin (0, 4, 8, and 16 ㎍/g of diet) were given to groups of 5 broiler chickens. In comet assay, The DNA damage was analysed by the tail extent moment (TEM) and tail length (TL), which were used as markers of DNA strand breaks in SCGE. A significant dose-dependent increase in the extent of DNA migration as well as in the percentage of cells with tails was observed after treatment with T-2 toxin (P＜0.05). Treatment with the low T-2 toxin (4 μ/g of diet) induced a relatively low level of DNA damage in comparison with the high T-2 toxin (16 μ/g of diet) group. The growth rate was significantly reduced by concentrations of 8, and 16 μ/g of diet (P ＜ 0.05). The feed conversion ratio were significantly affected by any concentrations (P ＜ 0.05). The relative weight of the spleen, and lung was decreased by the growth inhibitory concentrations. The bursa of Fabricius, thymus, and kidney were decreased in relative weight by concentrations of 16 μ/g of diet. The relative weight of the liver and heart were unaffected. The hemoglobin (Hb), hematocrit (HCT), and mean corpuscular hemoglobin (MCH) were decreased at concentration of 16 μ/g of diet. As compared with control chickens, there was no marked change in serum components except uric acid in T-2 treated chickens. All lymphoid tissues retained atrophic and lymphoid cell depletion throughout the three weeks trial.
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단세포전기영동법(Single Cell Gel Electrophoresis Assay)을 이용한 농약 살포자의 DNA손상 평가
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남성요인 불임에서 정액지표와 Comet Assay에 의한 정자 DNA 손상과의 관련성
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방사선조사된 채소류 및 곡물류의 DNA Comet Assay 특성 연구
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