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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.11 No.2
- 발행연도
- 2006.6
- 수록면
- 115 - 119 (5page)
이용수
초록· 키워드
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The object of this study was to examine whether the germanium fortified yeast administered to SD rat is accumulated in the liver and kidney. The administration doses were within 2,000 ㎎/㎏ which is the level of NOAEL (no observed adverse effect level) proved through the previous study of single/consecutive oral toxicity test. There were no significant clinical symptoms and mortality following the administration of organic germanium-fortified yeast (0, 500, 1,000, 2,000 ㎎/㎏) during the whole test period, and also no difference in the consumed amount of feed and water for each group. No significant abnormalities of hematology and blood chemistry parameters were found in all groups of organic germanium-fortified yeast (0, 500, 1,000, 2,000 ㎎/㎏). The amount of germanium accumulated in liver and kidney was 0 g/㎏ by ICP-AES method in the group of organic germanium-fortified yeast. In the positive control group of GeO₂ (150 ㎎/㎏), the amount of accumulation was shown to 3135.0 and 4277.2 g/kg in each female and male kidney and 1044.3 and 2135.8 g/㎏ in each female and male liver, respectively. Organic germanium-fortified yeast, a biosynthetic product resulting from putting germanium into yeast, did not show any clinical symptoms, blood chemical significance, and residues in kidney and liver. It could be inferred that the non-toxic amount of organic germanium-fortified yeast was up to 2,000 ㎎/㎏.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Tao SH, Bolger PM. 1997. Hazard assessment of germanium supplements. Regul Toxicol Pharmacol 25: 211-219.
Schauss AG. 1991. Nephrotoxicity and neurotoxicity in human from organogermanium compounds and germanium dioxide. Biol Trace Elem Res 29: 267-280.
Suzuki F, Brutkiewicz RR, Pollard RB. 1985. Importance of T-cells and macrophages in the antitumor activity of carboxyethylgermanium sesquioxide (Ge-132). Anticancer Res 5: 479-483.
Aso H, Suzuki F, Yamaguchi T, Hayashi Y, Ebina T, Ashida N. 1985. Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, and organic germanium compound. Microbiol Immunol 29: 65-74.
Hammett FS, Nowrey JE Jr, Muller JH. 1992. The erythropoietic action of germanium dioxide. J Exp Med 35: 173-180.
Schauss AG. 1991. Nephrotoxicity and neurotoxicity in human from organogermanium compounds and germanium dioxide. Biol Trace Elem Res 29: 267-280.
Suzuki F, Brutkiewicz RR, Pollard RB. 1985. Importance of T-cells and macrophages in the antitumor activity of carboxyethylgermanium sesquioxide (Ge-132). Anticancer Res 5: 479-483.
Aso H, Suzuki F, Yamaguchi T, Hayashi Y, Ebina T, Ashida N. 1985. Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, and organic germanium compound. Microbiol Immunol 29: 65-74.
Hammett FS, Nowrey JE Jr, Muller JH. 1992. The erythropoietic action of germanium dioxide. J Exp Med 35: 173-180.
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UCI(KEPA) : I410-ECN-0101-2009-511-015644592