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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국식품영양과학회 한국식품영양과학회지 한국식품영양과학회지 제35권 제5호
발행연도
2006.6
수록면
661 - 670 (10page)

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초록· 키워드

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Selenium (Se) obtained from dietary sources including cereals, grains and vegetables is an essential micronutrient for normal function of the body. Plants convert Se into selenomethionine and incorporate it into proteins in place of methionine, while higher animals synthesize selenoproteins containing selenocysteine. Excessive Se in the body is methylated stepwise to methylated selenium metabolites from selenide. Both inorganic and organic forms of selenium can be the nutritional sources in human, and they are transformed to selenide and then the amino acid selenocysteine attached to a specific tRNA<SUP>ser(sec)</SUP>. The selenocysteine (Sec) is incorporated into selenoprotein sequences by the UGA codon. The decoding of UGA as Sec requires specific mechanisms because UGA is normally read as a stop codon: cis -acting sequences in the mRNA (the sele-nocysteine insertion sequence, SECIS, within the 3’untranslated region) and trans -acting factors dedicated to Sec incorporation are required for incorporation of Sec during translation of selenoprotein mRNAs. Approxi-mately 25 selenoproteins have been identified in mammals. Several of these, including glutathione peroxidases, thioredoxin reductases and selenoprotein P, have been purified or cloned, allowing further characterization of their biological function. The antioxidant properties of selenoproteins help prevent cellular damage from free radicals which may contribute to the development of chronic disease such as cancer and heart disease. Other selenoproteins have important roles in regulation of thyroid function and play a role in the immune system. Daily selenium intake was reported to be 42.0±16.9 ㎍/day in Korean adult women. This review focuses on the metabolism and biological functions of selenium, and the nutritional status of selenium in the Korean population.

목차

Abstract
서론
셀레늄의 형태와 대사
셀레노시스테인과 셀레노단백질의 합성
셀레노단백질(Selenoproteins)
셀레늄과 건강
셀레늄과 영양
결론
감사의 글
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UCI(KEPA) : I410-ECN-0101-2009-511-015643904