지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The essential oil of Nardostachys jatamansi (Valerianaceae), which has been used for a long time in aroma therapy, was investigated after inhalation or oral administration for its analgesic effect, anticonvulsant action, hypnotic effect and in vitro inhibitory activity on monoamine oxidase. This fragrance oil showed a significant analgesic effect in the phenylquinone-induced writhing test, suppressed the convulsion induced by pentylenetetrazole and lengthened the pentobarbital-induced sleeping time in a time-dependent manner after fragrance inhalation or dose-independently by oral administration. Its inhibitory activity on monoamine oxidase was remarkable, showing 49.4% inhibition at a concentration of 5.0 ㎎/ml. Six new terpenes with seven known compounds were detected by our GC-MS analytical conditions used. As a result, the essential oil fragrance of Nardostachys jatamansi would be clinically useful for a sedative by either inhalation or oral administration.
목차
Abstract
재료 및 방법
결과 및 고찰
참고문헌
참고문헌 (24)
참고문헌 신청
Bircher, R. P., T. Kanai and S. C. Wang. 1962. Intravenous, cortical and intraventricular dose-effect relationship of pentylenetetrazol, picrotoxin and deslanoside in dogs. Electroencephalogr. Clin. Neurophysiol. 14, 256-267.
Bose, B. C., S. S. Gupta, J. N. Bhatnagar and R. Vijayvargiya. 1957. Nardostachys Jatamansi DC: its sedative and depressant action as estimated by Warburg technique. Indian Journal of Medical Sciences 11, 803-807.
Chatterjee, A., B. Basak, U. Datta, J. Banerji, A. Neuman and T. Prange. 2005. Studies on the chemical constituents of Nardostachys jatamansi DC (Valerianaceae). Ind. J. Chem. Section B: Organic Chemistry Including Medicinal Chemistry 44B, 430-433.
Gupta, S. S., C. B. Patel and V. S. Mathur. 1961. Effect of Nardostachys jatamansi fumes and aerosols in histamineinduced bronchial asthma in guinea pigs. Journal of the Indian Medical Association 37, 223-225.
Hendershot, L.C. and J. Forsaith. 1959. Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics. J. Pharm. Exptl. Therap. 125, 237-240.
Bose, B. C., S. S. Gupta, J. N. Bhatnagar and R. Vijayvargiya. 1957. Nardostachys Jatamansi DC: its sedative and depressant action as estimated by Warburg technique. Indian Journal of Medical Sciences 11, 803-807.
Chatterjee, A., B. Basak, U. Datta, J. Banerji, A. Neuman and T. Prange. 2005. Studies on the chemical constituents of Nardostachys jatamansi DC (Valerianaceae). Ind. J. Chem. Section B: Organic Chemistry Including Medicinal Chemistry 44B, 430-433.
Gupta, S. S., C. B. Patel and V. S. Mathur. 1961. Effect of Nardostachys jatamansi fumes and aerosols in histamineinduced bronchial asthma in guinea pigs. Journal of the Indian Medical Association 37, 223-225.
Hendershot, L.C. and J. Forsaith. 1959. Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics. J. Pharm. Exptl. Therap. 125, 237-240.
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