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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
동아시아식생활학회 동아시아식생활학회지 동아시아식생활학회지 제15권 제5호
발행연도
2005.10
수록면
606 - 612 (7page)

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This study was performed to provide basic data that predict the application of Saengmaegsan(SMS) as medicinal food. SMS has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. We examined the effects of SMS on physiological function in isolated abdominal aorta and femoral artery from rabbit. and measured the changes of regional cerebral bood flow(rCBF), which was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Spargue-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The contraction forces by injection of norephinephrine in isolated abdominal aorta and femoral artery were significantly decreased in each concentration of SMS treatment compared with control. rCBF was increased by SMS in a dose-dependent manner. These results suggest that SMS causes a diverse response of rCBF and arterial diameter. These mechanism in rCBF increase may be mediated by prostaglandis, cyclic GMP and adrenergic β-receptor. Also mechanism in artery contraction decrease is also mediated by prostaglandis and cyclic GMP. These results indicate that SMS can be used as a safe and clinically applicable as a supplementation of diet therapy for cerebral cardiovascular disease patients.

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UCI(KEPA) : I410-ECN-0101-2009-594-015329819