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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.11 No.4
- 발행연도
- 2006.12
- 수록면
- 289 - 297 (9page)
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This study examined the effect of hesperidin supplementation with an ethanol diet on lipid and antioxidant metabolism in rats. Male Sprague-Dawley rats were divided into two groups (n=10), and were assigned to one of two dietary categories: E?, ethanol diet (50 g/L) for 8 wks; E?H₄, ethanol diet for the first 4 wks and hesperidin (0.02%, w/w) supplemented ethanol diet for the last 4 wks. The plasma and hepatic lipids, hepatic cholesterol regulating enzyme activity, hepatic antioxidant enzyme activity and lipid peroxidation were determined. Supplementation with hesperidin for the last 4 wks during the 8 wks period of the ethanol diet, significantly increased the ADH activity. In conjunction with the chronic administration of ethanol, hesperidin supplementation resulted in a significant decrease in the hepatic cholesterol and triglyceride concentrations compared to the E? group. The hepatic HMG-CoA reductase and ACAT activities were significantly lower in the hesperidin-supplemented group. When comparing hepatic antioxidant enzyme activities, SOD, GSH-Px, and G6PD activities and GSH level were significantly higher in the E?H₄ group than in the E? group. Plasma TBARS levels were significantly lower in rats fed ethanol with hesperidin compared to the rats fed only ethanol; however, the hepatic TBARS levels were not significantly different between the groups. Accordingly, the additional hesperidin supplement with an ethanol diet might be effective for improving the hepatic lipid metabolism and antioxidant defense system.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (62)
참고문헌 신청
Lee HC, Lee HS, Jung SH, Yi SY, Jung HK, Yoon JH, Kim CY. 2001. Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. J Korean Med Sci 16: 745-750.
Bunout D. 1999. Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease. Nutrition 15: 583-589.
Crawford DW, Blankenhorn DH. 1991. Arterial wall oxygenation, oxyradicals and atherosclerosis. Atherosclerosis 89: 97-108.
Middleton E Jr, Drezewiecki G. 1984. Flavonoid inhibition of human basophil histamine release stimulated by various agents. Biochem Pharmacol 1: 3333-3338.
Pietta PG. 2000. Flavonoids as antioxidants. J Nat Prod 63: 1035-1042.
Bunout D. 1999. Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease. Nutrition 15: 583-589.
Crawford DW, Blankenhorn DH. 1991. Arterial wall oxygenation, oxyradicals and atherosclerosis. Atherosclerosis 89: 97-108.
Middleton E Jr, Drezewiecki G. 1984. Flavonoid inhibition of human basophil histamine release stimulated by various agents. Biochem Pharmacol 1: 3333-3338.
Pietta PG. 2000. Flavonoids as antioxidants. J Nat Prod 63: 1035-1042.
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