지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2004.11
- 수록면
- 17 - 23 (7page)
이용수
초록· 키워드
오류제보하기
Not all individuals respond identically, or at times in the same direction, to dietary interventions. These inconsistencies likely arise because of diet and genomic interactions (nutrigenomics effects). A host of factors may influence the response to bioactive food components including specific polymorphisms (nutrigenetic effect), DNA methylation patterns and other epigenomic factors (nutritional epigenomic effects), capacity to induce and/or suppress specific mRNA expression and patterns (nutritional transcriptomics), the occurrence and activity of proteins (proteomic effects), and/or the dose and temporal changes in cellular small molecular weight compounds will not only provide clues about specificity in response to food components, but assist in the identification of surrogate tissues and biomarkers that can predict a response. While this “discovery” phase is critical for defining mechanisms and targets, and thus those who will benefit most from intervention, its true usefulness depends on moving this understanding into “development” (interventions for better prevention, detection, diagnosis, and treatment) and a “delivery” phase where information is provided to those most in need. It is incumbent on those involved with food and nutrition to embrace the “omics” that relate to nutrition when considering not only the nutritional value of foods and their food components, but also when addressing acceptability and safety. The future of “Nutrigenomics and Health Promotion” depends on the ability of the scientific community to identify appropriate biomarkers and susceptibility variants, effective communications about the merits of such undertakings with the health care community and with consumers, and doing all of this within a responsible bioethical framework.
목차
ABSTRACT
Tissue and Cellular Assessment
Nutrigenetics
Epigenomics
Nutritional Transcriptomics
Proteomics
Metabolomics
Summary
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-511-018071540