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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 195 - 208 (14page)
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Diabetes is a major cause of morbidity and mortality, and associated with a high risk of atherosclerosis, and liver, kidney, nerve and tissue damage. Defective insulin secretion in pancreas and/or insulin resistance in peripheral tissues is a central component of diabetes. It is well established that, regardless of the degree of muscle insulin resistance, glucose levels in diabetic and non-diabetic individuals are determined by the rate of hepatic glucose production. Moreover recently studies using liver-specific insulin receptor knockout mice show the paramount role of the liver in insulin resistance and diabetes. Insulin exerts a multifaceted and highly integrated series of actions via its intracellular signaling systems. The first major section of this review defines the major insulin-mediated signaling pathways including phosphatidylinositol 3-kinase and mitogen activated protein kinases. The second major section of the review presents a summary and evaluation of methods for determination of the role and function of signaling pathways, including methods for determination of kinase phosphorylation, the use of pharmacological inhibitors of kinase and dominant-negative kinase constructs, and the application of new RNA interference methods.
목차
ABSTRACT
INTRODUCTION
INSULIN-MEDIATED SIGNALING PATHWAYS
METHODS FOR DETERMINATION OF INSULIN SIGNALING
CONCLUSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (73)
참고문헌 신청
, 2005 , 2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes
, 2004 , Acetoacetate activation of extracellular signal-regulated kinase 1, 2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes role of oxidative stress : 728 ~ 736
, 1996 , Mechanism of activation of protein kinase B by insulin and IGF-1 : 6541 ~ 6551
, 1995 , PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo : 27489 ~ 27494
, 2003 , Tolerance for mutations and chemical modifications in a siRNA : 589 ~ 595
, 2004 , Acetoacetate activation of extracellular signal-regulated kinase 1, 2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes role of oxidative stress : 728 ~ 736
, 1996 , Mechanism of activation of protein kinase B by insulin and IGF-1 : 6541 ~ 6551
, 1995 , PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo : 27489 ~ 27494
, 2003 , Tolerance for mutations and chemical modifications in a siRNA : 589 ~ 595
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UCI(KEPA) : I410-ECN-0101-2009-513-018052374